The mediodorsal thalamus in executive control

Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia

“… 13 We note that MDmc receives inputs from the DLPFC, in addition to inputs from the ventral PFC, 14 , 15 which may support the increased win-switching behavior after MDmc lesions. Animal work has shown that the thalamus, in partnership with the cortex, is a key nexus of perception and action 16 , 17 and a mediator of behavioral change in the face of evolving contingencies. 18 Yet, the MDmc has not been extensively implicated in human paranoia and thus warrants further investigation (but seeCrail-Melendez et al 19 ).…”