The Medicinal Halophyte Frankenia laevis L. (Sea Heath) Has In Vitro Antioxidant Activity, α-Glucosidase Inhibition, and Cytotoxicity towards Hepatocarcinoma Cells

Rodrigues, Maria João; Jekő, József; Cziáky, Zoltán; Pereira, Catarina; Custódio, Luísa

doi:10.3390/plants11101353

Cited by 10 publications

(24 citation statements)

References 49 publications

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“…ABTS scavenging capacity of SADE is similar to that of S. europea originating from Italy (ABTS = 15.1 mg TE/g) reported by Costa et al [ 49 ]. Halophyte plant extracts are characterized by promising in vitro antioxidant activities, as reported by many authors [ 19 , 22 , 50 ]. Phenolic acids such as ferulic acid, cinnamic acid, chlorogenic acid and coumaric acid were reported as the main phenolic compounds in many halophytes [ 18 , 37 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 88%

“…Many authors reported that the consumption of an HCD increases body weight and induces the accumulation of fat in adipose tissue. The accumulation of fat is the result of direct excess intake of a high-fat diet and/or the synthesis of fatty acids, mainly from carbohydrates [ 50 ]. The oral administration of SADE induced a decrease in body weight and adiposity index.…”

Section: Resultsmentioning

confidence: 99%

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Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Chrigui

Taieb

Jemai

et al. 2023

Foods

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Salicornia is a halophyte plant that has been used in traditional medicine for the treatment of scurvy, goiter, and hypertension. It is commercialized in Europe and Asia as fresh salads, pickled vegetables, green salt, or tea powder. This work is the first to assess the potential anti-obesity and anti-dyslipidemic effects of Salicornia arabica decocted extract (SADE). SADE was characterized by its significant in vitro radical scavenging activity (using DPPH and ABTS assays). The effect of SADE on food intake, weight loss, serum biochemical parameters, liver and kidney weights, adiposity index and on liver histology was investigated in the Tunisian gerbil Psammomys obesus (P. obesus), which is recognized as a relevant animal model of human obesity and diabetes. P. obesus animals were firstly randomly divided into two groups: the first received a natural low-calorie chow diet (LCD), and the second group received a high-calorie diet (HCD) over 12 weeks. On day 90, animals were divided into four groups receiving or not receiving SADE (LCD, LCD + SADE, HCD, and HCD + SADE). If compared to the HCD group, SADE oral administration (300 mg/kg per day during 4 weeks) in HCD + SADE group showed on day 120 a significant decrease in body weight (−34%), blood glucose (−47.85%), serum levels of total cholesterol (−54.92%), LDL cholesterol (−60%), triglycerides (−48.03%), and of the levels of hepatic enzymes: ASAT (−66.28%) and ALAT (−31.87%). Oral administration of SADE restored the relative liver weight and adiposity index and significantly limited HCD-induced hepatic injury in P. obesus. SADE seems to have promising in vivo anti-obesity and anti-dyslipidemic effects.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Chrigui

Taieb

Jemai

et al. 2023

Foods

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“…Usual therapeutic tools to prevent and/or ameliorate health conditions involve the inhibition of related key enzymes, as for example, α-glucosidase and α-amylase for diabetes (T2DM), cholinesterases (AChE, BChE) for Alzheimer’s disease and neurodegeneration, or tyrosinase for hyperpigmentation disorders [ 86 ]. Hence, efforts have been focused on identifying effective enzymatic inhibitors from natural sources [ 82 , 87 , 88 , 89 , 90 ]. In this sense, the enzyme inhibitory properties of extracts from sawgrass seeds were evaluated on the above-mentioned enzymes implicated with neurodegeneration (AChE and BChE), T2DM (α-glucosidase and α-amylase), and hyperpigmentation (tyrosinase), in view of their potential as source of phyto-therapeutic compounds and/or functional food ingredients ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

Nutritional and Phyto-Therapeutic Value of the Halophyte Cladium mariscus L. (Pohl.): A Special Focus on Seeds

Rodrigues

Custódio

Mecha

et al. 2022

Plants

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This work searched for the phyto-therapeutic potential and nutritional value of seeds from the halophyte Cladium mariscus L. (Pohl.), aiming at its use as a source of bioactive ingredients for the food industry. Hence, the nutritional profile, including minerals, of seeds biomass was determined; food-grade samples were prepared, and their phytochemical fingerprinting assessed. Extracts were evaluated for in vitro antioxidant potential, inhibitory capacity towards enzymes related to neuroprotection, diabetes, and hyperpigmentation, and anti-inflammatory properties, along with a toxicological assessment. Sawgrass seeds can be considered a proper nutritional source with a good supply of minerals. All extracts had a high level of total phenolics (65.3–394.4 mg GAE/g DW) and showed a chemically rich and diverse profile of metabolites that have several biological properties described (e.g., antioxidant, anti-inflammatory). Extracts had no significant toxicity (cell viabilities >80%) and were overall strong antioxidants (particularly at radical scavenging and reducing iron), effective tyrosinase inhibitors (55–71 mg KAE/g DW), showed anti-inflammatory properties (30–60% NO decrease), and had moderate capacity to inhibit enzymes related to neuroprotection (AChE 3.7–4.2, BChE 4.3–6.0 mg GALE/g DW) and diabetes (α-glucosidase 1.0–1.1, α-amylase 0.8–1.1 mmol ACAE/g). Altogether, results suggest that sawgrass seeds have the potential to be exploited as a new food product and are a reservoir of bioactive molecules with prospective applications as ingredients for value-added, functional, and/or preservative food products.

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“…PTC techniques have greatly contributed to industry and agriculture in the last 60 years by exploiting the economic potential of medicinal and crop plants [ 3 ]. Research on halophytes is increasing and focuses mainly on its biochemical properties and cultivation [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The application of tissue culture refers only to a few species [ 13 , 14 , 15 , 16 , 17 , 18 ], but already yielded the optimization of cosmetic ingredients of high commercial value (CELTOSOME TM ) from sea fennel and sea holly ( Eryngium maritimum ) [ 19 ].…”

Section: In Vitro Plant Tissue Culturementioning

confidence: 99%

Application of In Vitro Plant Tissue Culture Techniques to Halophyte Species: A Review

Custódio

Charles

Magné

et al. 2022

Plants

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Halophytes are plants able to thrive in environments characterized by severe abiotic conditions, including high salinity and high light intensity, drought/flooding, and temperature fluctuations. Several species have ethnomedicinal uses, and some are currently explored as sources of food and cosmetic ingredients. Halophytes are considered important alternative cash crops to be used in sustainable saline production systems, due to their ability to grow in saline conditions where conventional glycophyte crops cannot, such as salt-affected soils and saline irrigation water. In vitro plant tissue culture (PTC) techniques have greatly contributed to industry and agriculture in the last century by exploiting the economic potential of several commercial crop plants. The application of PTC to selected halophyte species can thus contribute for developing innovative production systems and obtaining halophyte-based bioactive products. This work aimed to put together and review for the first time the most relevant information on the application of PTC to halophytes. Several protocols were established for the micropropagation of different species. Various explant types have been used as starting materials (e.g., basal shoots and nodes, cotyledons, epicotyls, inflorescence, internodal segments, leaves, roots, rhizomes, stems, shoot tips, or zygotic embryos), involving different micropropagation techniques (e.g., node culture, direct or indirect shoot neoformation, caulogenesis, somatic embryogenesis, rooting, acclimatization, germplasm conservation and cryopreservation, and callogenesis and cell suspension cultures). In vitro systems were also used to study physiological, biochemical, and molecular processes in halophytes, such as functional and salt-tolerance studies. Thus, the application of PTC to halophytes may be used to improve their controlled multiplication and the selection of desired traits for the in vitro production of plants enriched in nutritional and functional components, as well as for the study of their resistance to salt stress.

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The Medicinal Halophyte Frankenia laevis L. (Sea Heath) Has In Vitro Antioxidant Activity, α-Glucosidase Inhibition, and Cytotoxicity towards Hepatocarcinoma Cells

Cited by 10 publications

References 49 publications

Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Anti-Obesity and Anti-Dyslipidemic Effects of Salicornia arabica Decocted Extract in Tunisian Psammomys obesus Fed a High-Calorie Diet

Nutritional and Phyto-Therapeutic Value of the Halophyte Cladium mariscus L. (Pohl.): A Special Focus on Seeds

Application of In Vitro Plant Tissue Culture Techniques to Halophyte Species: A Review

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