The medical plant butterbur (Petasites): Analytical and physiological (re)view

Aydın, Ahmet Alper; Zerbes, Valentin; Parlar, Harun; Letzel, Thomas

doi:10.1016/j.jpba.2012.11.028

Cited by 43 publications

(51 citation statements)

References 58 publications

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“…Traditional indications include the treatment of painful spasm, chiefly urinary tract pain and asthma. 20,35 Although some research has demonstrated the antispasmodic properties of petasites extracts, which may underlie their popularity, relevant clinical evidence for their use remains limited. However, use of butterbur as an antiasthmatic agent is supported by some clinical data.…”

Section: Butterbur: the Plant And Its Usesmentioning

confidence: 99%

“…19 Both have a common chemical profile dominated by sesquiterpenes. 19,20 There are also some reports on the use of St John's wort (Hypericum perforatum, Hypericaceae, flowering aerial parts) for the treatment of migraine attacks. Its chemistry is characterized by the naphthodianthrone hypericine 21 but it is now known that both butterbur and St John's wort contain significant amounts of melatonin, a deficit of which has been related to migraine.…”

Section: Introduction To Herbal Therapies In Migraine Prophylaxismentioning

confidence: 99%

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Update on the efficacy and safety of Petadolex®, a butterbur extract for migraine prophylaxis

Prieto¹

2014

BTAT

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Migraine has a heavy socioeconomic impact in terms of lost productivity and burden on the health care system. The efficacy of current drug regimens in migraine prophylaxis is limited, and therapeutic alternatives are needed. These include a range of herbal medicines based on butterbur, feverfew, St John's wort, and Ginkgo. Of these, Petadolex ® , an extract of the butterbur root, is the most promising. Petadolex ® has been investigated in four studies, including one good quality clinical trial involving 202 patients, two randomized controlled trials with smaller cohorts including adults and children, and a large observational, open-label study. However, post-marketing surveillance only supports its safety at lower doses and over treatment durations shorter than those used in the clinical trials. Moreover, the long-term safety of the product has been called into question, leading to withdrawal in some European countries. This review draws an overall picture of this complex set of data. The safety and efficacy of Petadolex ® remains a matter of debate by a number of clinical, regulatory, and professional bodies.

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Section: Butterbur: the Plant And Its Usesmentioning

confidence: 99%

Section: Introduction To Herbal Therapies In Migraine Prophylaxismentioning

confidence: 99%

Update on the efficacy and safety of Petadolex®, a butterbur extract for migraine prophylaxis

Prieto¹

2014

BTAT

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“…4) and petasin rich extracts [8,20] since the changes in petasin concentrations between leaves and rhizomes of the plant are not tremendous [3]. …”

Section: Structure Elucidation Of Bakkenolide Bmentioning

confidence: 99%

Isolation, Quality Evaluation, and Seasonal Changes of Bakkenolide B in Petasites japonicus by HPLC

Kim¹,

Kim²,

Jung³

et al. 2014

Journal of Life Science

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The leaves of Peatasites japonicus are a traditional oriental medicine with diverse biological activities.A simple and specific analytical method for the quantitative determination of bakkenolide B constituents from methanolic extract of the leaves of P. japonicus was developed. Bakkenolide B was isolated from the leaves of P. japonicus, and its structure was elucidated based on 1D, 2D NMR, and GC-MS spectral data. A liquid chromatographic method was developed to evaluate the quality of P. japonicus through determination of major active compound, bakkenolide B. The wavelengths at 254 and 215 nm were chosen to determine bakkenolide B. The recovery of the method was in the range of 98.6 to 103.1%, and bakkenolide B showed good linearity (r 2 =0.999) within test ranges. The developed method was applied to the determination of bakkenolide B in the plant part and seasonal changes. The results showed that the content of bakkenolide B in the leaf was higher than in the petiole and rhizome. In this study, a simple, rapid, and reliable high-performance liquid chromatography method was used to determine the percentage and composition of bakkenolide B in P. japonicus procured from different Petasites species plants in South Korea. The method can be employed in routine quantitative analysis and quality control of different products in the market.

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“…P. japonicus is reportedly used in treating asthma, hypertension, headaches, and gastrointestinal problems, whereas F. japonicum is used to heal sore throats, fever, eczema, and coughs. [4][5][6] Moreover, extracts from these genera have exhibited various biological activities such as antiallergenic, neuroprotective, and anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Bakkenolide D in Petasites japonicus and Farfugium japonicum by HPLC/UV

Quilantang

Lee

et al. 2017

Nat Prod Sci

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− A quantitative analysis of bakkenolide D in the different parts of Petasites japonicus and Farfugium japonicum was performed by HPLC. A gradient HPLC elution system with a mobile phase consisting of water: acetonitrile solution (20:80 to 0:100 for 45 min) was followed and an INNO C 18 column was used for the chromatographic separation. The injection volume, flow rate, and UV detection were 10 µL, 1 mL/min, and 290 nm, respectively. Results show that both species showed the highest amount of bakkenolide D in the roots being 107.203 and 166.103 mg/g for P. japonicas and F. japonicum, respectively. Content analysis on the different parts of both plants displayed remarkably lower values which ranged from 0.403 -4.419 and 7.252 -32.614 mg/g for P. japonicas and F. japonicum, respectively. The results show that the roots of both plants are rich in bakkenolide D showing a promising use in the development of nutraceuticals and industrial application of the compound.

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The medical plant butterbur (Petasites): Analytical and physiological (re)view

Cited by 43 publications

References 58 publications

Update on the efficacy and safety of Petadolex®, a butterbur extract for migraine prophylaxis

Update on the efficacy and safety of Petadolex®, a butterbur extract for migraine prophylaxis

Isolation, Quality Evaluation, and Seasonal Changes of Bakkenolide B in Petasites japonicus by HPLC

Quantitative Determination of Bakkenolide D in Petasites japonicus and Farfugium japonicum by HPLC/UV

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The medical plant butterbur (Petasites): Analytical and physiological (re)view

Cited by 43 publications

References 58 publications

Update on the efficacy and safety of Petadolex&reg;, a butterbur extract for migraine prophylaxis

Update on the efficacy and safety of Petadolex&reg;, a butterbur extract for migraine prophylaxis

Isolation, Quality Evaluation, and Seasonal Changes of Bakkenolide B in Petasites japonicus by HPLC

Quantitative Determination of Bakkenolide D in Petasites japonicus and Farfugium japonicum by HPLC/UV

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Product

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Update on the efficacy and safety of Petadolex®, a butterbur extract for migraine prophylaxis

Update on the efficacy and safety of Petadolex®, a butterbur extract for migraine prophylaxis