The Mediating Role of Hope in the Relationship Between Perceived Stress and Post-Traumatic Stress Disorder Among Chinese Patients with Oral Cancer: A Cross-Sectional Study

Zhang, Ying; Cui, Chunying; Wang, Lie; Yu, Xin; Wang, Yu; Wang, Xiaoxi

doi:10.2147/cmar.s281886

Cited by 16 publications

(15 citation statements)

References 47 publications

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“…Our data also showed that perceived stress is positively related to PTSD symptoms, which confirmed the finding of previous studies conducted in other contexts such as ongoing terrorist attacks (Besser et al, 2009 ) and oral cancer (Zhang et al, 2021 ). Ikizer et al ( 2021 ) also found the same association in the context of the COVID-19 Pandemic, suggesting that this result could be explained by the limited access to psychological resources that generally help to cope with an unexpected aversive event.…”

Section: Discussionsupporting

confidence: 92%

“…To date, only two studies have examined the association between perceived stress and PTSD symptoms in two different stressful situations: civilian exposition to ongoing terrorist attacks (Besser et al, 2009 ) and oral cancer (Zhang et al, 2021 ). Both studies have found that PTSD symptoms were positively associated with perceived stress (Besser et al, 2009 ; Zhang et al, 2021 ). In the context of COVID-19 Pandemic, Ikizer et al ( 2021 ) found similar results in a sample of 685 Turkish participants.…”

Section: Introductionmentioning

confidence: 99%

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The longitudinal association between Perceived Stress, PTSD Symptoms, and Post-Traumatic Growth during the COVID-19 Pandemic: the role of coping strategies and psychological inflexibility

et al. 2022

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The present study investigates the mediating roles of psychological inflexibility and differential coping strategies on perceived stress and post-traumatic symptoms and growth in the context of COVID-19. Study one recruited 662 participants (54.8% women; Mage = 40.64 years, SD = 13.04) who completed a cross-sectional questionnaire. It was proposed that orientation to the problem, avoidance strategies, psychological inflexibility, and positive attitude were mediators for the positive association between perceived stress and PTSD symptoms. The fit indices for the path model were excellent: CFI = 0.977, TLI = 0.950, RMSEA = 0.057 [90%CI = 0.043–0.081], and SRMS = 0.042. Gender and stressful events encountered had indirect effects on the endogenous variables. In study two, 128 participants (57.8% women; Mage = 42.30, SD = 12.08) were assessed for post-traumatic growth one year later. Psychological inflexibility and orientation acted as mediators between perceived stress and PTSD symptoms. Furthermore, a novel path model was constructed in which psychological inflexibility and orientation to the problem as mediators for perceived stress and PTSD symptoms. The indices for the path model were excellent: CFI = 0.99, TLI = 0.97, RMSEA = 0.055 [90%CI = 0.001–0.144], and SRMS = 0.49. Furthermore, PTSD symptoms, psychological inflexibility, and orientation to the problem predicted post-traumatic growth. Specifically, both orientation to the problem (β = .06 [90%CI: .01;.13]) and psychological inflexibility (β = .14 [90%CI: .08;.26]) had an indirect effect on post-traumatic growth. Overall, these results significantly contribute to the literature as orientation to the problem positively predicted PTSD symptoms and post-traumatic growth one year later while psychological inflexibility predicted PTSD symptoms and less post-traumatic growth one year later. These results underline the importance of assessing both symptomology and psychological growth to determine adaptive coping strategies in specific contexts.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The longitudinal association between Perceived Stress, PTSD Symptoms, and Post-Traumatic Growth during the COVID-19 Pandemic: the role of coping strategies and psychological inflexibility

et al. 2022

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“…Higher PSS-10 total score means greater level of perceived stress. The Chinese version of PSS-10 demonstrated satisfactory reliability and validity ( Liu et al., 2021 ; Wang et al., 2021a ; Zhang et al., 2021 ). In this survey, Cronbach's α coefficient of internal consistency of this scale was 0.722.…”

Section: Methodsmentioning

confidence: 92%

Analysis of the resilience level and associated factors among patients with lumbar disc herniation

Zhang

Dai

Chu

et al. 2022

Heliyon

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“…The EPM has been well-validated to detect responses to anxiety and exploratory behavior in mice ( Zhang Y. et al, 2021 ). A maze made entirely of stainless steel, painted blue, was positioned 40 cm above the ground and consisted of two open arms (30 × 5 cm each), two closed arms (30 × 5 cm each, arm height 25 cm), and a central platform (5 × 5 cm), arranged in the shape of a cross.…”

Section: Animal Experimentsmentioning

confidence: 99%

Valeriana jatamansi Jones ex Roxb. Against Post-Traumatic Stress Disorder, Network Pharmacological Analysis, and In Vivo Evaluation

et al. 2021

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Zhi zhu xiang (ZZX) is the root and rhizome of Valeriana jatamansi Jones ex Roxb. Recent studies have shown that ZZX can exert antianxiety, antidepressant, and sedative effects. Because post-traumatic stress disorder (PTSD) is similar to depression and anxiety in terms of its etiology, pathogenesis, and clinical manifestations, it is possible that ZZX may also be useful for the prevention and treatment of PTSD. In this study, a mouse model of PTSD was established and used to study the pharmacological action of a 95% ethanol extract of ZZX on PTSD via a series of classic behavioral tests. We found that a 95% ethanol extract of ZZX was indeed effective for relieving the symptoms of PTSD in mice. Moreover, network pharmacology analysis was used to predict the potential active ingredients, targets, and possible pathways of ZZX in the treatment of PTSD. The neurotransmitter system, the hypothalamic–pituitary–adrenal (HPA) axis, and the endocannabinoid (eCB) system were identified to be the most likely pathways for anti-PTSD action in ZZX. Due to the lack of a falsification mechanism in network pharmacology, in vivo tests were carried out in mice, and the expression levels of neurotransmitters, hormones, and genes of key targets were detected by enzyme-linked immunosorbent assay and real-time PCR to further verify this inference. Analysis showed that the levels of norepinephrine, 5-hydroxytryptamine, and glutamic acid were increased in the hippocampus, prefrontal cortex, and amygdala of PTSD mice, while the levels of dopamine and γ-aminobutyric acid were decreased in these brain regions; furthermore, ZZX could restore the expression of these factors, at least to a certain extent. The levels of adrenocorticotropic hormone, corticosterone, and corticotropin-releasing hormone were increased in these different brain regions and the serum of PTSD mice; these effects could be reversed by ZZX to a certain extent. The expression levels of cannabinoid receptor 1 and diacylglycerol lipase α mRNA were decreased in PTSD mice, while the levels of fatty acid amide hydrolase and monoacylglycerol lipase mRNA were increased; these effects were restored by ZZX to a certain extent. In conclusion, our findings suggest that ZZX may provide new therapeutic pathways for treating PTSD by the regulation of neurotransmitters, the HPA, and expression levels of eCB-related genes in the brain.

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The Mediating Role of Hope in the Relationship Between Perceived Stress and Post-Traumatic Stress Disorder Among Chinese Patients with Oral Cancer: A Cross-Sectional Study

Abstract: Post-traumatic stress and relationships to coping and alexithymia in patients with psychogenic non-epileptic seizures. Seizure, 57, 70-75.

Cited by 16 publications

References 47 publications

The longitudinal association between Perceived Stress, PTSD Symptoms, and Post-Traumatic Growth during the COVID-19 Pandemic: the role of coping strategies and psychological inflexibility

The longitudinal association between Perceived Stress, PTSD Symptoms, and Post-Traumatic Growth during the COVID-19 Pandemic: the role of coping strategies and psychological inflexibility

Analysis of the resilience level and associated factors among patients with lumbar disc herniation

Valeriana jatamansi Jones ex Roxb. Against Post-Traumatic Stress Disorder, Network Pharmacological Analysis, and In Vivo Evaluation

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