The mediating function of obesity on endocrine-disrupting chemicals and insulin resistance in children

Li, Lingli; Xu, Shanshan; Lian, Qiang

doi:10.1515/jpem-2022-0354

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…112 Recent meta-analysis showed that Benzophenone-3 (Bp-3) level might be a risk factor for IR in children, and obesity seems to be the mediator in the relationship between BP-3 and IR in children. 113…”

Section: Basis Of Endocrine-disrupting Chemicalsrelated Insulin Resis...mentioning

confidence: 99%

Insulin Resistance in Children and the role of Endocrine-Disrupting Chemicals: Taking Stock of the Situation

Forcucci

Chiarelli

2023

MRAJ

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The prevalence of non-communicable diseases, of which insulin resistance is a major constituent, among the pediatric population is exponentially increasing worldwide; this is causing a significant health burden, making understanding the basis of this phenomenon an issue of primary importance. During the last decades, we also observed that exposure to endocrine-disrupting chemicals is becoming more and more common; this has led researchers to investigate the mechanism of action and define the role of those substances in interfering with human metabolism and hormonal balance, especially at a young age. We reviewed the literature on prospective, epidemiological, and cross-sectional studies that have shown a link between exposure to pesticides, polychlorinated biphenyls, bisphenol A, phthalates, aromatic polycyclic hydrocarbons, or dioxins and insulin resistance; the strength of the associations varies between the substances and human biomonitoring studies have helped in defining the role of these chemicals. The number of prospective studies in children and even in adults is still low and heterogenous, still, evidence that Endocrine disruptors might be involved in the development of insulin resistance and related diseases is accumulating. This review aims to analyze the latest findings linking exposure to endocrine-disrupting chemicals with insulin resistance in children with the perspective of taking a cue for conducting new studies and identifying the most concerning Endocrine disruptors exposures, in order to guide future risk assessment and policy action aimed to limit the negative consequences of endocrine disrupting chemical exposure.

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Section: Basis Of Endocrine-disrupting Chemicalsrelated Insulin Resis...mentioning

confidence: 99%

Insulin Resistance in Children and the role of Endocrine-Disrupting Chemicals: Taking Stock of the Situation

Forcucci

Chiarelli

2023

MRAJ

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Safety of benzophenone-type UV filters: A mini review focusing on carcinogenicity, reproductive and developmental toxicity

Wang

Qin

et al. 2023

Chemosphere

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The combined effects of overweight/obesity and dietary antioxidant quality score on hypertension in children and adolescents

Zhong,

Zhang,

2023

BMC Pediatr

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Background This study was to evaluate the combined effects of overweight/obesity and DAQS on the risk of hypertension in children and adolescents. Methods In this cross-sectional study, the data of 14,316 subjects were extracted from the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression analysis was used to explore the associations of obesity and DAQS with the risk of hypertension. The combined effect of overweight/obesity and DAQS on the risk of hypertension was evaluated. Results Body mass index (BMI)-for-age < 85th percentile was associated with reduced risk of hypertension in children and adolescents [odds ratio (OR) = 0.48, 95% confidence interval (CI): 0.41–0.62]. No significant association between DAQS ≥ 3 and the risk of hypertension before and after the adjustment of confounders (P > 0.05). Subjects with BMI-for-age of < 85th percentile and DAQS < 3 was associated with decreased risk of hypertension (OR = 0.53, 95%CI: 0.35–0.79). People with BMI-for-age of < 85th percentile and DAQS ≥ 3 was correlated with decreased risk of hypertension (OR = 0.52, 95%CI: 0.36–0.74). Subgroup analysis revealed that in subjects aged ≥ 12 years, decreased risk of hypertension was observed in BMI-for-age < 85th percentile and DAQS < 3 group (OR = 0.48, 95%CI: 0.31–0.73) as well as BMI-for-age < 85th percentile and DAQS ≥ 3 group (OR = 0.47, 95%CI: 0.32–0.67). In boys, BMI-for-age < 85th percentile and DAQS < 3 group (OR = 0.45, 95%CI: 0.25–0.81) as well as BMI-for-age < 85th percentile and DAQS ≥ 3 group (OR = 0.40, 95%CI: 0.25–0.65) were correlated with decreased risk of hypertension. Conclusion Overweight/obesity and DAQS had combined effects on the risk of hypertension in children and adolescents, which implied that for children and adolescents with normal weight, to keep normal weight combined with high quality of diet might be recommended.

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The mediating function of obesity on endocrine-disrupting chemicals and insulin resistance in children

Cited by 3 publications

References 26 publications

Insulin Resistance in Children and the role of Endocrine-Disrupting Chemicals: Taking Stock of the Situation

Insulin Resistance in Children and the role of Endocrine-Disrupting Chemicals: Taking Stock of the Situation

Safety of benzophenone-type UV filters: A mini review focusing on carcinogenicity, reproductive and developmental toxicity

The combined effects of overweight/obesity and dietary antioxidant quality score on hypertension in children and adolescents

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