The organizational performance at Punjab healthcare is crucial and often faces stockouts of critical medicines and equipment at the emergency department of different hospitals, which increased the mortality rate. Therefore, the study determined the effect of disruptive factors and inventory control as a mediator on organizational performance. The quantitative method with survey questionnaires on a 200 sample size through cluster sampling was used. SPSS and AMOS were used to examine Exploratory Factor Analysis, Confirmatory Factor Analysis, and Structural Equation Modeling. The results found full mediation with a significant positive effect between study variables. The finding indicated that the strict compliance of standardized operating procedures, professionally well-equipped staff, stock availability, and accurate inventories could reduce costs with improved service quality. This study is useful to the public healthcare facilities, ministries managing inventories, and to the body of knowledge. Finally, the backlog inventories at public sector organizations need to be researched in the future. Contribution/Originality: This study is one of very few investigating the mediating effect of inventory control on the relationship between disruptive factors and organizational performance. The study also contributes a secondorder construct model, identifying the dimensions within those constructs, to the existing literature. 1. INTRODUCTION According to Rashid., Amirah, and Yusof (2019) organizational performance is a crucial entity, especially the healthcare performance as it involves the patients, clinicians, broader public, and the government. Besides, public healthcare facilities usually are criticized and alleged for poor accountability, misuse of resources, and maladministration (Silva & Ferreira, 2010). Because of the vital role of healthcare, in budget 2015-16, the Health Department allocated 168 billion rupees (PKR) for primary and secondary healthcare (Rashid. et al., 2019). Despite having a colossal amount, the increased mortality rate upshot. Only in December 2015, the Punjab Institute of Cardiology found 112 deaths and 46,000 patients at high risks due to stocked-out and expired batches of curative accessories and medicines. The Department of Health went through hasty buying cost 5.6 billion PKR with 56 million PKR for compensation of dead victims. The shortage of Hepatitis C (HVC) vaccine was found at 98 out of 145 hospitals. The infant mortality was 89 per thousand, which were 78 per thousand in 2008. The maternal