The mediating and interacting role of physical activity and sedentary behavior between diabetes and depression in people with obesity in United States

Huang, Baoying; Huang, Zhenhui; Tan, Jianyi; Xu, Huafu; Deng, Kaisheng; Cheng, Jinqun; Ren, Zhiqiang; Gong, Xiao; Gao, Yanhui

doi:10.1016/j.jdiacomp.2020.107764

Cited by 15 publications

(8 citation statements)

References 30 publications

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“…Diabetes was defined as having a fasting plasma glucose (FPG) level of more than 126 mg/dL or a glycated hemoglobin (HbA1c) level of at least 6.5% or having a physician-diagnosed diagnosis of DM ( 13 , 24 , 25 ). Diabetic visual impairment was confirmed using a dichotomous, self-reported item, indicating that a doctor had informed the respondent that diabetes had affected their eyes.…”

Section: Methodsmentioning

confidence: 99%

Associations between psycho-behavioral risk factors and diabetic retinopathy: NHANES (2005–2018)

Sun

Zhang

Guo

et al. 2022

Front. Public Health

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Section: Methodsmentioning

confidence: 99%

Associations between psycho-behavioral risk factors and diabetic retinopathy: NHANES (2005–2018)

Sun

Zhang

Guo

et al. 2022

Front. Public Health

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“…Depression had synergistic effects with obesity on diabetes incidence in Chinese adults 132 . Likewise, patients with diabetes and obesity had an increased risk of depression 133 . Moreover, another research found that the link between insulin resistance and depression possibly resulted from the over‐adjustment of central obesity 10 .…”

Section: Mechanismsmentioning

confidence: 99%

Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

Li,

Yang,

Zhou

et al. 2023

CNS Neurosci Ther

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BackgroundThe comorbidity between diabetes mellitus and depression was revealed, and diabetes mellitus increased the prevalence of depressive disorder, which ranked 13th in the leading causes of disability‐adjusted life‐years. Insulin resistance, which is common in diabetes mellitus, has increased the risk of depressive symptoms in both humans and animals. However, the mechanisms behind the comorbidity are multi‐factorial and complicated. There is still no causal chain to explain the comorbidity exactly. Moreover, Selective serotonin reuptake inhibitors, insulin and metformin, which are recommended for treating diabetes mellitus‐induced depression, were found to be a risk factor in some complications of diabetes.AimsGiven these problems, many researchers made remarkable efforts to analyze diabetes complicating depression from different aspects, including insulin resistance, stress and Hypothalamic–Pituitary–Adrenal axis, neurological system, oxidative stress, and inflammation. Drug therapy, such as Hydrogen Sulfide, Cannabidiol, Ascorbic Acid and Hesperidin, are conducive to alleviating diabetes mellitus and depression. Here, we reviewed the exact pathophysiology underlying the comorbidity between depressive disorder and diabetes mellitus and drug therapy.MethodsThe review refers to the available literature in PubMed and Web of Science, searching critical terms related to diabetes mellitus, depression and drug therapy.ResultsIn this review, we found that brain structure and function, neurogenesis, brain‐derived neurotrophic factor and glucose and lipid metabolism were involved in the pathophysiology of the comorbidity. Obesity might lead to diabetes mellitus and depression through reduced adiponectin and increased leptin and resistin. In addition, drug therapy displayed in this review could expand the region of potential therapy.ConclusionsThe review summarizes the mechanisms underlying the comorbidity. It also overviews drug therapy with anti‐diabetic and anti‐depressant effects.

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“…Similarly, light exercise volume was defined as less than 150 min per week of moderate-intensity aerobic exercise or equivalent status. In addition, on the basis of self-reported sedentary behavior, sedentary status was categorized as follows: more than 480 min/day as severe and less than 480 min/day as mild sedentary behavior (36,37).…”

Section: Exposure: Exercise Activity and Sedentary Behaviormentioning

confidence: 99%

The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers

et al. 2023

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BackgroundTwo related lifestyle behaviors associated with sleep disturbance are sedentary behavior and physical exercise participation. We aimed to use a population-based study to disentangle the relationships between sedentary behavior, exercise, and sleep disturbance based on blood-cell-based inflammatory biomarkers.MethodsA total of 22,599 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sleep disturbance was assessed according to the NHANES questionnaire. Exercise participation ansd sedentary behavior were evaluated by the global physical activity questionnaire. The inflammatory biomarkers in the examination were white blood cell (WBC) count, neutrophil count (NEU), neutrophil-to-lymphocyte ratio (NLR), and systemic immune inflammation index (SII). A complex multistage sampling design and weighted multivariable logistic regression were applied for further analysis. Mediation models were constructed to figure out the mediating role of inflammatory biomarkers.ResultsThe weighted prevalence of sleep disturbance was 24.17%. Sedentary behavior and exercise were associated with sleep disturbance after full adjustment [for sedentary behavior, OR (95% CI): 1.261 (1.154, 1.377); for exercise, OR (95% CI): 0.849 (0.757, 0.953)]. In severe sedentary behavior groups, the mitigation effect of exercise on sleep disturbance was observed [OR (95% CI): 0.687 (0.551, 0.857)]. For the mechanism, strong associations were detected between inflammatory biomarkers and sleep disturbance. Mediation analysis showed that WBC, NEU, NLR, and SII mediated the statistical association between sedentary behavior and sleep disturbance with proportions (%) of 2.09, 2.27, 1.76, and 0.82, respectively.ConclusionsOur data suggested that sedentary behavior was a risk factor for sleep disturbance. Blood-cell-based inflammatory biomarkers were an easily accessible and cost-effective strategy for identifying sleep disturbance and also significantly mediated the association between sedentary behavior and sleep disturbance. Exercise was proved to be effective in severe sedentary behavior groups to improve sleep disturbance symptoms, while the internal mechanism needed further exploration.

show abstract

The mediating and interacting role of physical activity and sedentary behavior between diabetes and depression in people with obesity in United States

Cited by 15 publications

References 30 publications

Associations between psycho-behavioral risk factors and diabetic retinopathy: NHANES (2005–2018)

Associations between psycho-behavioral risk factors and diabetic retinopathy: NHANES (2005–2018)

Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression

The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers

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