The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients:a randomized controlled trial
Abstract:Background: Propofol may result in hypotension, bradycardia,
and loss of protective reflexes, especially in elderly patients, while
esketamine, a N-methyl-D-aspartate receptor antagonists, has analgesic,
anaesthetic and sympathomimetic properties and is known to cause less
cardiorespiratory depression. We hypothesized that esketamine may reduce
the median effective concentration (EC50) of propofol and cause more
stable haemodynamic responses during gastrointestinal endoscopy in
elderly patients. Methods: Ninet… Show more
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