The Mechanisms of the Interaction of Stable Isotopes with Biological Objects in the Presence of an Uncompensated Neutron in Chemical Bonds

Елкина, А. А.; Tumaev, E. N.; Басов, А. А.; Моисеев, А. В.; Малышко, В. В.; Barisheva, E. V.; Churkina, A. V.; Джимак, С. С.

doi:10.1134/s0006350920050048

Cited by 2 publications

(4 citation statements)

References 44 publications

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“…The participation of deuterium atoms in the formation of hydrogen bonds in a DNA molecule can provide a significant change in the time of genetic information transmission which suggests that even a slight isotopic shift in the environment can affect the rate of metabolic processes [37][38][39][40][41][42][43][44][45][46][47][48][49][50]. The carried out studies on the 2 H/ 1 H isotope exchange effect…”

Section: Discussionmentioning

confidence: 99%

“…The participation of deuterium atoms in the formation of hydrogen bonds in a DNA molecule can provide a significant change in the time of genetic information transmission, which suggests that even a slight isotopic shift in the environment can affect the rate of metabolic processes [37][38][39][40][41][42][43][44][45][46][47][48][49][50]. The carried out studies on the 2 H/ 1 H isotope exchange effect in hydrogen bonds between pairs of nitrogenous bases on the inequality distribution of the probabilities of open states along the length of the gene showed that an external action in the frequency range from 10 11 s −1 to 10 8 s −1 causes vibration of the DNA molecule with a frequency different from the frequency of external influence.…”

Section: Discussionmentioning

confidence: 99%

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Influence of a Single Deuterium Substitution for Protium on the Frequency Generation of Different-Size Bubbles in IFNA17

Basov,

Dorohova,

Malyshko

et al. 2023

IJMS

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The influence of a single 2H/1H replacement on the frequency generation of different-size bubbles in the human interferon alpha-17 gene (IFNA17) under various energies was studied by a developed algorithm and mathematical modeling without simplifications or averaging. This new approach showed the efficacy of researching DNA bubbles and open states both when all hydrogen bonds in nitrogenous base pairs are protium and after an 2H-substitution. After a single deuterium substitution under specific energies, it was demonstrated that the non-coding region of IFNA17 had a more significant regulatory role in bubble generation in the whole gene than the promoter had. It was revealed that a single deuterium substitution for protium has an influence on the frequency generation of DNA bubbles, which also depends on their size and is always higher for the smaller bubbles under the largest number of the studied energies. Wherein, compared to the natural condition under the same critical value of energy, the bigger raises of the bubble frequency occurrence (maximums) were found for 11–30 base pair (bp) bubbles (higher by 319%), 2–4 bp bubbles (higher by 300%), and 31 bp and over ones (higher by 220%); whereas the most significant reductions of the indicators (minimums) were observed for 11–30 bp bubbles (lower by 43%) and bubbles size over 30 bp (lower by 82%). In this study, we also analyzed the impact of several circumstances on the AT/GC ratio in the formation of DNA bubbles, both under natural conditions and after a single hydrogen isotope exchange. Moreover, based on the obtained data, substantial positive and inverse correlations were revealed between the AT/GC ratio and some factors (energy values, size of DNA bubbles). So, this modeling and variant of the modified algorithm, adapted for researching DNA bubbles, can be useful to study the regulation of replication and transcription in the genes under different isotopic substitutions in the nucleobases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of a Single Deuterium Substitution for Protium on the Frequency Generation of Different-Size Bubbles in IFNA17

Basov,

Dorohova,

Malyshko

et al. 2023

IJMS

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“…The influence of the isotopic 2 H-effect on nucleic acids structure and their functions is being actively studied, and it is relevant for various fields of science [ 19 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. So, our data allows to understand the mechanism of the possible changes in the OS occurrence frequency in IFNA17 by the single 2 H/ 1 H-replacement under specific energy range more precisely.…”

Section: Discussionmentioning

confidence: 99%

“…The participation of deuterium atoms in the formation of hydrogen bonds in the DNA molecule can cause a change in the time of transmission of genetic information, thus, even a slight change in the isotopic state of the medium can affect changes in metabolic processes in living systems [ 15 , 16 , 17 ]. It is known that non-radioactive isotopes of biogenic elements ( 2 H/ 1 H, 13 C/ 12 C, 15 N/ 14 N, 18 O/ 17 O/ 16 O) have a significant effect on the rate of biochemical reactions, physiological processes, growth, and development of unicellular and multicellular living organisms with different levels of organization of energy metabolism and metabolic rate [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range

Басов

Drobotenko

Svidlov

et al. 2022

IJMS

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The effect of single substitutions of protium for deuterium in hydrogen bonds between pairs of nitrogenous bases on the open states occurrence probability at high critical breaking energies of these bonds has been studied. The study was carried out using numerical methods based on the angular mathematical model of DNA. The IFNA17 gene was divided into three approximately equal parts. A comparison of the open states occurrence probability in these parts of the gene was done. To improve the accuracy of the results, a special data processing algorithm was developed. The developed methods have shown their suitability for taking into account the occurrence of open states in the entire range of high critical energies. It has been established that single 2H/1H substitutions in certain nitrogenous bases can be a mechanism for maintaining the vital activity of IFNA17 under critical conditions. In general, the developed method of the mathematical modeling provide unprecedented insight into the DNA behavior under the highest critical energy range, which greatly expands scientific understanding of nucleobases interaction.

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The Mechanisms of the Interaction of Stable Isotopes with Biological Objects in the Presence of an Uncompensated Neutron in Chemical Bonds

Cited by 2 publications

References 44 publications

Influence of a Single Deuterium Substitution for Protium on the Frequency Generation of Different-Size Bubbles in IFNA17

Influence of a Single Deuterium Substitution for Protium on the Frequency Generation of Different-Size Bubbles in IFNA17

Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range

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