The mechanisms of mutual relationship between malignant hematologic cells and mesenchymal stem cells: Does it contradict the nursing role of mesenchymal stem cells?

Goodarzi, Alireza; Valikhani, Mohsen; Amiri, Fatemeh; Safari, Armita

doi:10.1186/s12964-022-00822-6

Cited by 8 publications

(7 citation statements)

References 131 publications

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“… 234 Via releasing microvesicles, LSCs can promote the survival and migration of AML cells and regulate AML malignancy. 247 It has been found that overexpression of miR-34a can inhibit this effect of LSCs by altering the downstream target genes, including caspase-3 and T-cell immunoglobulin mucin-3. miR-34a is a tumor-suppressive molecule associated with AML cell growth and invasion.…”

Section: Signaling Pathways Governing Lsc Maintenancementioning

confidence: 99%

Signaling pathways governing the behaviors of leukemia stem cells

Azizidoost¹,

Nasrolahi²,

Sheykhi-Sabzehpoush³

et al. 2024

Genes & Diseases

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Section: Signaling Pathways Governing Lsc Maintenancementioning

confidence: 99%

Signaling pathways governing the behaviors of leukemia stem cells

Azizidoost¹,

Nasrolahi²,

Sheykhi-Sabzehpoush³

et al. 2024

Genes & Diseases

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“…As we have seen, communication between MM and BM-MSCs cells can take place through mechanisms that can be classified as contact-dependent and/or contact-independent mechanisms[ 115 ]. While the previous section has been dedicated to direct communication mediated by cell adhesion molecules, in this last section we will briefly discuss transport via tunneling nanotubes (TNTs), another form of contact-dependent interaction.…”

Section: Communication Through Contact Dependent Mechanismsmentioning

confidence: 99%

Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression

García-Sánchez,

González-González,

Alfonso-Fernández

et al. 2023

World J Stem Cells

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Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow (BM). The interaction between MM cells and the BM microenvironment, and specifically BM mesenchymal stem cells (BM-MSCs), has a key role in the pathophysiology of this disease. Multiple data support the idea that BM-MSCs not only enhance the proliferation and survival of MM cells but are also involved in the resistance of MM cells to certain drugs, aiding the progression of this hematological tumor. The relation of MM cells with the resident BM-MSCs is a two-way interaction. MM modulate the behavior of BM-MSCs altering their expression profile, proliferation rate, osteogenic potential, and expression of senescence markers. In turn, modified BM-MSCs can produce a set of cytokines that would modulate the BM microenvironment to favor disease progression. The interaction between MM cells and BM-MSCs can be mediated by the secretion of a variety of soluble factors and extracellular vesicles carrying microRNAs, long non-coding RNAs or other molecules. However, the communication between these two types of cells could also involve a direct physical interaction through adhesion molecules or tunneling nanotubes. Thus, understanding the way this communication works and developing strategies to interfere in the process, would preclude the expansion of the MM cells and might offer alternative treatments for this incurable disease.

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“…In experimental mouse models, it has been shown that VLA-4 blocking antibodies are able to reduce minimal residual disease and favour AML survival [ 135 ]. CXCL12 is just one of several soluble factors (see below) constitutively expressed by MSCs that can stimulate AML cell survival [ 136 , 137 ]. Targeting its CXCR4 receptor (by antagonist or neutralizing antibodies) reduced AML burden and disease progression without affecting HSC engraftment [ 138 ].…”

Section: The Effect Of Leukemic Cells On Mesenchymal Stem Cell Proper...mentioning

confidence: 99%

Bone Marrow Aging and the Leukaemia-Induced Senescence of Mesenchymal Stem/Stromal Cells: Exploring Similarities

Ruiz-Aparicio

Vernot

2022

JPM

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Bone marrow aging is associated with multiple cellular dysfunctions, including perturbed haematopoiesis, the propensity to haematological transformation, and the maintenance of leukaemia. It has been shown that instructive signals from different leukemic cells are delivered to stromal cells to remodel the bone marrow into a supportive leukemic niche. In particular, cellular senescence, a physiological program with both beneficial and deleterious effects on the health of the organisms, may be responsible for the increased incidence of haematological malignancies in the elderly and for the survival of diverse leukemic cells. Here, we will review the connection between BM aging and cellular senescence and the role that these processes play in leukaemia progression. Specifically, we discuss the role of mesenchymal stem cells as a central component of the supportive niche. Due to the specificity of the genetic defects present in leukaemia, one would think that bone marrow alterations would also have particular changes, making it difficult to envisage a shared therapeutic use. We have tried to summarize the coincident features present in BM stromal cells during aging and senescence and in two different leukaemias, acute myeloid leukaemia, with high frequency in the elderly, and B-acute lymphoblastic leukaemia, mainly a childhood disease. We propose that mesenchymal stem cells are similarly affected in these different leukaemias, and that the changes that we observed in terms of cellular function, redox balance, genetics and epigenetics, soluble factor repertoire and stemness are equivalent to those occurring during BM aging and cellular senescence. These coincident features may be used to explore strategies useful to treat various haematological malignancies.

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The mechanisms of mutual relationship between malignant hematologic cells and mesenchymal stem cells: Does it contradict the nursing role of mesenchymal stem cells?

Cited by 8 publications

References 131 publications

Signaling pathways governing the behaviors of leukemia stem cells

Signaling pathways governing the behaviors of leukemia stem cells

Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression

Bone Marrow Aging and the Leukaemia-Induced Senescence of Mesenchymal Stem/Stromal Cells: Exploring Similarities

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