The mechanisms of leukocyte removal by filtration

Bruil, Anton; Beugeling, T.; Feijén, Jan; Aken, W.G. van

doi:10.1016/s0887-7963(05)80053-7

Cited by 84 publications

(67 citation statements)

References 179 publications

(8 reference statements)

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“…The latter has been thought to be part of the mechanism involved in leucocyte removal by filtration [12, 13, 14]. This may also explain the earlier reports showing that filtration did not induce platelet activation measured by CD62P in the filtrate [2].…”

Section: Discussionmentioning

confidence: 70%

Are All Leucodepleted Platelet Concentrates Equivalent?

Krailadsiri¹,

Seghatchian²

2000

Vox Sanguinis

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Background and Objectives: A number of technologies are available for the production of leucocyte–depleted platelet concentrates (PCs). This study compared the characteristics of PCs prepared by three commonly used techniques. Materials and Methods: In total, fifteen units of leucoyte–depleted PCs prepared by the Cobe LRS Turbo apheresis system, Haemonetics MCS+ with in–line filter and filtration of PCs derived from pooled buffy coats (BCs) were transferred into the same standard container. Markers to assess status/activation and microvesiculation of platelets as well as platelet injury were measured. Results: pH was well maintained in all types of PCs. The expression of CD62P was higher in Cobe LRS Turbo on day 1 but became equivalent between the three methods on day 5. A significant correlation was found between the expression of CD62P on platelet surface and soluble CD62P in the plasma. The degree of phosphatidylserine (PS) exposure was slightly higher in Cobe LRS Turbo and BC–PCs than Haemonetics MCS+ on day 1. However, on day 5 both apheresis PC values were higher than BC–PCs. A significant correlation was found between PS exposure and microvesiculation. Conclusion: Leucodepleted PCs prepared by the three methods were different in terms of storage lesion and microvesiculation. The clinical significance of these findings remains to be investigated.

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Section: Discussionmentioning

confidence: 70%

Are All Leucodepleted Platelet Concentrates Equivalent?

Krailadsiri¹,

Seghatchian²

2000

Vox Sanguinis

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“…Leukocytes have a negative zeta potential [53] and therefore are prone to interact strongly with the positive surface of the NiNW. However, other types of interactions are certainly involved, such as hydrogen bonding between groups on the leukocyte membrane and electronegative nitrogen atoms of PEI [52][53][54]. Moreover, it has been widely accepted that surface wettability and hydrophilicity also influence the adhesion of leukocytes [53,54].…”

Section: Resultsmentioning

confidence: 99%

“…In some situations, such as in blood transfusion, it is necessary to reduce the concentration of leukocytes in blood, in order to prevent leukocyte-mediated adverse effects [51,54,55]. Therefore, the materials described here may contribute to develop additional tools for the depletion of leukocytes, taking advantage of the ferromagnetic properties of nickel nanowires.…”

Section: Resultsmentioning

confidence: 99%

Functionalization of nickel nanowires with a fluorophore aiming at new probes for multimodal bioanalysis

Pinheiro

Sousa

Araújo

et al. 2013

Journal of Colloid and Interface Science

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This work reports research on the development of bimodal magnetic and fluorescent 1D nanoprobes. First, ferromagnetic nickel nanowires (NiNW) have been prepared by Ni electrodeposition in anodic aluminum oxide (AAO) template. The highly ordered self-assembled AAO nanoporous templates were fabricated using a two-step anodization method of aluminum foil. The surface of the NiNW were then modified with polyethyleneimine (PEI) which was previously labeled with an organic dye (fluorescein isothiocyanate: FITC) via covalent bonding. The ensuing functionalized NiNW exhibited the characteristic green fluorescence of FITC and could be magnetically separated from aqueous solutions by using a NdFeB magnet. Finally, the interest of these bimodal NiNW as nanoprobes for in vitro cell separation and biolabeling was preliminary assessed in a proof of principle experiment that involved the attachment of biofunctionalized NiNW to blood cells.

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“…이러한 수혈이상반응을 예방하기 위해 백혈구 제거 혈액제제에 대한 연구가 활발히 진행되었고 [3][4][5][6][7][8], 그 유용성이 입증됨에 따라 프랑스를 시작 으로 해외의 많은 국가들은 모든 헌혈혈액에서 저 장 전에 백혈구를 제거하는 정책(Universal Leukocyte Reduction, ULR)을 시행하고 있다 [9][10][11]. ULR 정책 도입 전과 도입 후를 비교하였을 때 비용혈 성발열반응 발생률 [12,13], HLA 항원에 대한 동 종면역반응으로 생성된 동종항체에 의한 혈소판 수혈불응증 발생률 [14] Table 1에 있는 공식으로 계산하였다 [17,18].…”

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Proposal of Evaluation Method for Leukoreduction Blood Filter and Evaluation of Domestic Filter

Shin

Kim

et al. 2017

KJBT

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Background: A leukoreduction filter was recently developed in Korea to reduce various kinds of adverse transfusion reactions. The objective of this study was to propose a domestic evaluation system for leukoreduction filters and to apply this evaluation system to assess the newly developed leukoreduction filter. Methods: We prepared packed red blood cells from 60 units of whole blood (400 mL) collected from 60 normal individuals and evaluated the efficacy of the newly developed filter (FINECELL, KOLON INDUSTRIES, Gumi, Korea) and a control filter (RCM1, Haemonetics, MA, USA). To verify the evaluation system, we assessed the filtration time, residual leukocyte count, RBC recovery, RBC hemolysis, hemoglobin concentration, and hematocrit using a control filter RCM1 and compared the results with those of an evaluation performed by the American Red Cross (ARC) in 2013. We then evaluated the efficacy of the test filter FINECELL using the methods established in this study and compared the results with those of the control filter RCM1. Results:The results of the current study were similar to those of the ARC with the control filters. The test filters developed in Korea were not inferior to commonly used control filters regarding residual leukocyte count, RBC recovery, and RBC hemolysis at 35 days after filtration. All of the results in the evaluation satisfied the international standards. Conclusion: These results of this study showed that the efficacy of the newly developed domestic leukoreduction filter were satisfactory and will contribute to improvement of quality of blood components in Korea. (Korean J

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The mechanisms of leukocyte removal by filtration

Cited by 84 publications

References 179 publications

Are All Leucodepleted Platelet Concentrates Equivalent?

Are All Leucodepleted Platelet Concentrates Equivalent?

Functionalization of nickel nanowires with a fluorophore aiming at new probes for multimodal bioanalysis

Proposal of Evaluation Method for Leukoreduction Blood Filter and Evaluation of Domestic Filter

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