The Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends?

Tan, Shuzheng; Kong, Ying; Xian, Yongtong; Gao, Pengbo; Wei, Chuzhong; Lin, Peixu; Ye, Weilong; Li, Zesong; Zhu, Xiao

doi:10.3389/fmolb.2022.938677

Cited by 6 publications

(3 citation statements)

References 140 publications

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“…Theoretically, FasL- or TRAIL-induced necroptotic death could occur in cells with inactivated cFLIP L when apoptotic pathways are suppressed by FSH signaling, but this hypothetical event has to be confirmed experimentally in vitro and in vivo. Ferroptosis is inhibited by PI3K/AKT signaling [ 215 ] and can be promoted by autophagic degradation of ferritin [ 216 ]. Therefore, it could be prone to occur in combination with autophagy when pre-antral follicles receive insufficient FSH.…”

Section: Regulation Of Pcd During Follicular Atresiamentioning

confidence: 99%

A matter of new life and cell death: programmed cell death in the mammalian ovary

Chesnokov,

Mamedova,

Zhivotovsky

et al. 2024

J Biomed Sci

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Background The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproductive period. The estrous/menstrual cycles are associated with drastic functional and morphological rearrangements of ovarian tissue, including follicular development and degeneration, and the formation and subsequent atrophy of the corpus luteum. The flawless execution of these reiterative processes is impossible without the involvement of programmed cell death (PCD). Main text PCD is crucial for efficient and careful clearance of excessive, depleted, or obsolete ovarian structures for ovarian cycling. Moreover, PCD facilitates selection of high-quality oocytes and formation of the ovarian reserve during embryonic and juvenile development. Disruption of PCD regulation can heavily impact the ovarian functions and is associated with various pathologies, from a moderate decrease in fertility to severe hormonal disturbance, complete loss of reproductive function, and tumorigenesis. This comprehensive review aims to provide updated information on the role of PCD in various processes occurring in normal and pathologic ovaries. Three major events of PCD in the ovary—progenitor germ cell depletion, follicular atresia, and corpus luteum degradation—are described, alongside the detailed information on molecular regulation of these processes, highlighting the contribution of apoptosis, autophagy, necroptosis, and ferroptosis. Ultimately, the current knowledge of PCD aberrations associated with pathologies, such as polycystic ovarian syndrome, premature ovarian insufficiency, and tumors of ovarian origin, is outlined. Conclusion PCD is an essential element in ovarian development, functions and pathologies. A thorough understanding of molecular mechanisms regulating PCD events is required for future advances in the diagnosis and management of various disorders of the ovary and the female reproductive system in general.

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Section: Regulation Of Pcd During Follicular Atresiamentioning

confidence: 99%

A matter of new life and cell death: programmed cell death in the mammalian ovary

Chesnokov,

Mamedova,

Zhivotovsky

et al. 2024

J Biomed Sci

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“…After ICH, ferrous ions overload, GPX4 deficiency, and PLOOHs cannot be cleared in time pointing to the susceptibility of the fenton chemistry. Overload ROS that exceeds the antioxidant capacity of cells leads to an enhanced oxidative stress response, which directly or indirectly damages proteins, nucleic acids, lipids, and other macromolecular substances ( Tan et al, 2022 ). Finally, the membrane is damaged and the cell collapses and dies due to the lipid peroxidation inside the phospholipid of the cell membrane.…”

Section: The Underlying Mechanisms Of Ferroptosis In Ichmentioning

confidence: 99%

Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage

Cao

Xiao²,

Liu³

et al. 2023

Front. Cell. Neurosci.

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Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high rates of morbidity, mortality, and disability. Optimal treatment of ICH is a major clinical challenge, as the underlying mechanisms remain unclear. Ferroptosis, a newly identified form of non-apoptotic programmed cell death, is characterized by the iron-induced accumulation of lipid reactive oxygen species (ROS), leading to intracellular oxidative stress. Lipid ROS causes damage to nucleic acids, proteins, and cell membranes, eventually resulting in ferroptosis. In the past 10 years, ferroptosis has resulted in plenty of discoveries and breakthroughs in cancer, neurodegeneration, and other diseases. Some studies have also reported that ferroptosis does occur after ICH in vitro and in vivo and contribute to neuronal death. However, the studies on ferroptosis following ICH are still in the preliminary stage. In this review, we will summarize the current evidence on the mechanism underlying ferroptosis after ICH. And review the traditional modes of neuronal death to identify the crosstalk with ferroptosis in ICH, including apoptosis, necroptosis, and autophagy. Additionally, we also aim to explore the promising therapeutic application of ferroptosis in cell death-based ICH.

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“…Ferroptosis is a form of iron‐dependent, non‐apoptotic cell death characterized by distinct morphological, biological, and genetic features when compared to other regulated cell death mechanisms like apoptosis, necrosis, and autophagy. 8 Ferroptosis is marked by an excess production of iron‐dependent intracellular oxygen free radicals, resulting in lipid peroxidation and accumulation, ultimately leading to cell membrane rupture. 9 This process is intricately linked to the maintenance of internal environmental homeostasis and the development of various diseases, particularly cancer.…”

Section: Introductionmentioning

confidence: 99%

A ferroptosis‐related LncRNAs signature for predicting prognoses and screening potential therapeutic drugs in patients with lung adenocarcinoma: A retrospective study

Dong,

Tao,

et al. 2023

Cancer Reports

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BackgroundLung adenocarcinoma (LUAD) has a high mortality rate. Ferroptosis is linked to tumor initiation and progression.AimsThis study aims to develop prognostic models of ferroptosis‐related lncRNAs, evaluate the correlation between differentially expressed genes and tumor microenvironment, and identify prospective drugs for managing LUAD.Methods and ResultsIn this study, transcriptomic and clinical data were downloaded from the TCGA database, and ferroptosis‐related genes were obtained from the FerrDb database. Through correlation analysis, Cox analysis, and the LASSO algorithm for constructing a prognostic model, we found that ferroptosis‐related lncRNA‐based gene signatures (FLncSig) had a strong prognostic predicting ability in the LUAD patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichments reconfirmed that ferroptosis is related to receptor‐ligand activity, enzyme inhibitor activity, and the IL‐17 signaling pathway. Next, tumor mutation burden (TMB), tumor immune dysfunction and exclusion (TIDE) algorithms, and pRRophetic were used to predict immunotherapy response and chemotherapy sensitivity. The IMvigor210 cohort was also used to validate the prognostic model. In the tumor microenvironment, Type_II_IFN_Response and HLA were found to be a group of low‐risk pathways, while MHC_class_I was a group of high‐risk pathways. Patients in the high‐risk subgroup had lower TIDE scores. Exclusion, MDSC, CAF, and TAMM2 were significantly and positively correlated with risk scores. In addition, we found 15 potential therapeutic drugs for LUAD. Finally, differential analysis of stemness index based on mRNA expression (mRNAsi) indicated that mRNAsi was correlated with gender, primary tumor (T), distant metastasis (M), and the tumor, node, and metastasis (TNM) stage in LUAD patients.ConclusionsIn conclusion, the prognostic model based on FLncSig can alleviate the difficulty in predicting the prognosis and immunotherapy of LUAD patients. The identified FLncSig and the screened drugs exhibit potential for clinical application and provide references for the treatment of LUAD.

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The Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends?

Cited by 6 publications

References 140 publications

A matter of new life and cell death: programmed cell death in the mammalian ovary

A matter of new life and cell death: programmed cell death in the mammalian ovary

Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage

A ferroptosis‐related LncRNAs signature for predicting prognoses and screening potential therapeutic drugs in patients with lung adenocarcinoma: A retrospective study

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