The mechanisms of action of metformin on head and neck cancer in the pre-clinical setting: a scoping review
Lucy Huang,
Charmaine M. Woods,
Nuwan Dharmawardana
et al.
Abstract:This scoping review identifies the mechanistic pathways of metformin when used to treat head and neck cancer cells, in the pre-clinical setting. Understanding the underlying mechanisms will inform future experimental designs exploring metformin as a potential adjuvant for head and neck cancer. This scoping review was conducted according to the Joanna-Briggs Institute framework. A structured search identified 1288 studies, of which 52 studies fulfilled the eligibility screen. The studies are presented in themes… Show more
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