The mechanisms involved in the increased adiposity induced by interruption of regular physical exercise practice

Sertié, Rogério Antônio Laurato; Curi, Rui; Oliveira, Ariclécio Cunha de; Andreotti, Sandra; Caminhotto, R.O.; Lima, Thaís Martins de; Proença, André Ricardo Gomes de; Reis, Gabriela Boltes; Lima, Fábio Bessa

doi:10.1016/j.lfs.2019.02.051

Cited by 14 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After the resting period, these animals were also characterized by an increase in body weight, and their final body weight corresponded to the body mass of sedentary subjects. While food consumption was not investigated in this study [34], Tokuyama and colleagues demonstrated that physical activity correlates with increased feed intake compared to sedentary controls [35]. This finding was not confirmed using our experimental design.…”

Section: Discussioncontrasting

confidence: 60%

“…Comparable results were described in rats that stopped training four weeks earlier than their littermates, which trained for a total of 12 weeks [34]. After the resting period, these animals were also characterized by an increase in body weight, and their final body weight corresponded to the body mass of sedentary subjects.…”

Section: Discussionmentioning

confidence: 52%

“…No significant changes in subcutaneous, perinephric, and epididymal fat depot mass were detected in the animals of both lines that stopped exercising in the second part of our experiment. Sertie et al made similar observations with rats undergoing 12 weeks of treadmill training [34]. Early discontinuation of training after eight weeks followed by 4-weeks of sedentary caging resulted in subcutaneous and retroperitoneal fat mass weights similar to those of entirely untrained animals, while those of permanently trained siblings were reduced.…”

Section: Discussionmentioning

confidence: 74%

See 2 more Smart Citations

Analysis of Activity-Dependent Energy Metabolism in Mice Reveals Regulation of Mitochondrial Fission and Fusion mRNA by Voluntary Physical Exercise in Subcutaneous Fat from Male Marathon Mice (DUhTP)

Brenmoehl

Ohde

Walz

et al. 2020

Cells

View full text Add to dashboard Cite

Physical inactivity is considered as one of the main causes of obesity in modern civilizations, and it has been demonstrated that resistance training programs can be used to reduce fat mass. The effects of voluntary exercise on energy metabolism are less clear in adipose tissue. Therefore, the effects of three different voluntary exercise programs on the control of energy metabolism in subcutaneous fat were tested in two different mouse lines. In a cross-over study design, male mice were kept for three or six weeks in the presence or absence of running wheels. For the experiment, mice with increased running capacity (DUhTP) were used and compared to controls (DUC). Body and organ weight, feed intake, and voluntary running wheel activity were recorded. In subcutaneous fat, gene expression of browning markers and mitochondrial energy metabolism were analyzed. Exercise increased heart weight in control mice (p < 0.05) but significantly decreased subcutaneous, epididymal, perinephric, and brown fat mass in both genetic groups (p < 0.05). Gene expression analysis revealed higher expression of browning markers and individual complex subunits present in the electron transport chain in subcutaneous fat of DUhTP mice compared to controls (DUC; p < 0.01), independent of physical activity. While in control mice, voluntary exercise had no effect on markers of mitochondrial fission or fusion, in DUhTP mice, reduced mitochondrial DNA, transcription factor Nrf1, fission- (Dnm1), and fusion-relevant transcripts (Mfn1 and 2) were observed in response to voluntary physical activity (p < 0.05). Our findings indicate that the superior running abilities in DUhTP mice, on one hand, are connected to elevated expression of genetic markers for browning and oxidative phosphorylation in subcutaneous fat. In subcutaneous fat from DUhTP but not in unselected control mice, we further demonstrate reduced expression of genes for mitochondrial fission and fusion in response to voluntary physical activity.

show abstract

Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 74%

See 1 more Smart Citation

Analysis of Activity-Dependent Energy Metabolism in Mice Reveals Regulation of Mitochondrial Fission and Fusion mRNA by Voluntary Physical Exercise in Subcutaneous Fat from Male Marathon Mice (DUhTP)

Brenmoehl

Ohde

Walz

et al. 2020

Cells

View full text Add to dashboard Cite

show abstract

“…This is reinforced by the results of lower final weight and lower weight variation found in the RDAT group when compared to the RDS group, without significant difference between RDAT and HS groups, and show the positive effects of physical exercise on renal function (discussed previously) and body composition, because HIAT increases energy expenditure which can justify the change in body composition. The literature shows that these effects are physical exercise intensity dependent and related to the release of catecholamines, growth hormone, oxygen consumption after exercise, lipoprotein lipase activity and improvement of the insulin response that usually affect the mobilization of triacylglycerol and in the oxidation rate, resulting in reduction of fat mass 18 .…”

Section: Discussionmentioning

confidence: 99%

Muscle changes with high-intensity aerobic training in an animal model of renal disease

Togoe

Silva²,

Cury

et al. 2019

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose: To analyze the muscle changes with high-intensity aerobic training (HIAT) in an animal model of renal disease (RD). Methods: Twenty one adult Wistar rats were divided into 3 groups: healthy sedentary (HS), RD sedentary (RDS), RD aerobic training (RDAT). RDS and RDAT were subjected to unilateral renal ischemia-reperfusion (10 min) and 21days after that, RDAT was subjected to 6 weeks HIAT (swimming). Serum creatinine (Cr) and muscle morphometry (cross-sectional area = CSA) of gastrocnemius were analyzed. Results: Cr was higher (p = 0.0053) in RDS (0.82 ± 0.04) than in the others (RDAT 0.55 ± 0.04; HS 0.55 ± 0.04). Morphometric analysis (class interval of CSA in μm 2 /absolute frequency of muscle fibers in each class) indicated that 50th percentile occurred in: HS 7th class (3000.00-3499.00/515), RDS, 8th class (3500.00-3999.00/484), RDAT 5th class (2000.00-2499.00/856). CSA of largest fibers in RDS, RDAT, HS was 9953.00 μm 2 , 9969.00 μm 2 ,11228.00 μm 2 , respectively. High frequency of fibers with lower CSA occurred in 4th, 5th, 6th and 7th class in RDA, absence of fibers into 22nd, 23rd classes (RDS and RDAT). Conclusion: HIAT in an animal model of RD resulted in increased the number of muscle fibers with smaller CSA.

show abstract

“…11 Although this might lead to a reduction of adiposity and favorable changes in the lipid profile, 12 it is possible that adipose tissue undergoes a compensatory effect. [13][14][15] The compensatory effect on fat-related outcomes has been investigated in endurance athletes who showed elevated intramuscular lipid storages 16 which is called the "endurance paradox." On the other hand, these effects should also be expected on adipose tissue, especially after exercise cessation and might explain fat regain.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise cessation on adipose tissue physiological markers related to fat regain: A systematic review

et al. 2020

View full text Add to dashboard Cite

Tissues usually super compensate during the period that follow physical exercise. Although this is widely accepted for muscle and glycogen, the compensatory effect is not usually applied to fat tissues. Notwithstanding, evidence for this has been present since the 1970s when it was first suggested that the increased lipogenic activity in response to training might be an adaptation that enables to restore an energy reserve that can be used in times of need. In this context, the present review aimed to summarize information about the effect of detraining on fat metabolism and the physiological responses associated with fat regain. A systematic search on PubMed and Scielo was performed using “training cessation,” “detraining,” “exercise detraining,” and “exercise cessation” combined with “fat tissue,” “adipose tissue,” “adipose metabolism,” and “fat metabolism,” as descriptors. From 377 results, 25 were included in this review, 12 humans and 13 rodents, resulting in a sample of 6772 humans and 613 animals. The analysis provided evidence for fat super compensation, as well as differences in humans and rodents, among different protocols and possible mechanisms for fat gain after exercise cessation. In summary, exercise cessation appears to increase the ability of the adipose tissue to store energy. However, caution should be taken, especially regarding conclusions based on investigations on humans, considering the multiple factors that could affect fat metabolism.

show abstract

The mechanisms involved in the increased adiposity induced by interruption of regular physical exercise practice

Cited by 14 publications

References 37 publications

Analysis of Activity-Dependent Energy Metabolism in Mice Reveals Regulation of Mitochondrial Fission and Fusion mRNA by Voluntary Physical Exercise in Subcutaneous Fat from Male Marathon Mice (DUhTP)

Analysis of Activity-Dependent Energy Metabolism in Mice Reveals Regulation of Mitochondrial Fission and Fusion mRNA by Voluntary Physical Exercise in Subcutaneous Fat from Male Marathon Mice (DUhTP)

Muscle changes with high-intensity aerobic training in an animal model of renal disease

Effects of exercise cessation on adipose tissue physiological markers related to fat regain: A systematic review

Contact Info

Product

Resources

About