The Mechanisms and Effects of Physical Activity on Breast Cancer

Boer, Myrte C. de; Wörner, Elisabeth; Verlaan, Diede; Leeuwen, Paul A. M. van

doi:10.1016/j.clbc.2017.01.006

Cited by 102 publications

(128 citation statements)

References 66 publications

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“…It is thought that the weight of breast cancer patients within 1 year after surgery is not influenced by a reduction in aerobic clearly as in other studies (Brown et al, 2015;Simonavice et al, 2015;Wirtz & Baumann, 2018). Fatness and decreased physical activity are known to be associated with mortality and recurrence of breast cancer (de Boer, Wörner, Verlaan, & Leeuwen, 2017). The guideline for managing breast cancer survivors encourages them to increase their physical activity (Smith & Chagpar, 2010).…”

Section: Discussionmentioning

confidence: 91%

“…However, even if it does not affect overall QOL, physical activity and fatness, it would be necessary to provide appropriate intervention because there were groups with impairment clearly as in other studies (Brown et al, ; Simonavice et al, ; Wirtz & Baumann, ). Fatness and decreased physical activity are known to be associated with mortality and recurrence of breast cancer (de Boer, Wörner, Verlaan, & Leeuwen, ). The guideline for managing breast cancer survivors encourages them to increase their physical activity (Smith & Chagpar, ).…”

Section: Discussionmentioning

confidence: 99%

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Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

Kim

Park

2019

Eur J Cancer Care

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To investigate the relation of physical functions to health‐related quality of life (HRQOL), physical activity and fatness of patients during breast cancer treatment within 1 year after surgery. We retrospectively reviewed the patients with breast cancer at the cancer rehabilitation clinic within 1 year after surgery. Physical function assessment included aerobic capacity, muscle strength, flexibility and oedema. Physical activity was assessed using the International Physical Activity Questionnaire‐Short Form, and HRQOL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Stepwise multivariate linear regression analysis was used to find the association factors. Of the physical functions in subjects, aerobic capacity was 88.64% compared to predictive value. The mean overall QOL was 60.82 ± 20.98. The mean physical activity was 2,245.49 ± 3,687.66 MET/week and 39 patients (41.5%) were inactive. As the results of stepwise multivariate linear regression analysis, aerobic capacity was a significant factor of HRQOL and physical activity. The impairment of physical functions affects the HRQOL of patients within 1 year after breast cancer surgery. Among the physical functions, the decrease in aerobic capacity was significantly associated with the decrease in the overall QOL of the patients.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

Kim

Park

2019

Eur J Cancer Care

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“…Physical inactivity may be associated with an increased risk of breast cancer through several biological mechanisms. Women with high levels of leisure-time physical activity (LTPA) have lower serum estradiol and higher sex hormone-binding globulin levels after adjusting for obesity and this association is more pronounce in post-menopausal compared to pre-menopausal breast cancer (14,15). Exercise may influence breast cancer risk by inducing systemic anti-inflammatory effect and other effects that may be mediated through the reduced visceral fat mass.…”

Section: Introductionmentioning

confidence: 99%

“…Exercise may influence breast cancer risk by inducing systemic anti-inflammatory effect and other effects that may be mediated through the reduced visceral fat mass. (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

“…Whereas acute physical activity is associated with oxidative stress, human adaptation to repeated exercise leads to the development of protective anti-oxidant effect associated with reduced cancer progression and metastasis (15,18). In addition, physical activity reduces circulating leptin and insulin levels, and insulin resistance while increasing adiponectin, IGFBP-1 and IGFBP-3 levels (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

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Leisure-Time Physical Activity is Associated with reduced Risk of Breast Cancer and Triple Negative Breast Cancer in Nigerian Women: a matched case-control study

Bigman

Adebamowo

Yawe

et al. 2019

Preprint

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Background Physical activity is associated with reduced risk of breast cancer and its various subtypes but this association is less known in African women, particularly with triple-negative breast cancer that occurs more frequently in Sub-Saharan Africa compared to developed countries. In this study, we examined the association between leisure-time physical activity (LTPA) and breast cancer in total and by its subtypes in Nigerian women. Methods Overall, 630 newly diagnosed patients with primary invasive breast cancer were age-matched (±5years) with 630 controls from the Nigerian Integrative Epidemiology of Breast Cancer (NIBBLE) Study from 01/2014-07/2016. We derived the average amount of time spent on LTPA per week over the past year using a modified Nurses’ Health Study-II physical activity questionnaire. We calculated the total metabolic equivalents (METs) for each reported LTPA per hour/week (i.e. walking, cycling, and dancing) and compared odds of breast cancer among participants who attained the World Health Organization (WHO) physical activity(PA) recommendations of at least 150 minutes of moderate-intensity or/and 75 minutes of vigorous-intensity aerobic activity/week with those who did not. In addition, we evaluated this by categories of LTPA in quartiles of METs. We used conditional and unconditional logistic regression models to estimate the adjusted Odds Ratio(OR) of LTPA with overall breast cancer and by hormone receptor-positive and triple-negative breast cancer. Results The mean ages of cases and controls were similar after matching, 42.5±10.1 and 41.5±9.2 years (mean±SD), respectively. Women who attained the WHO PA recommendations had a 42% reduction in the odds of having breast cancer(OR=0.58 95% CI:0.43-0.78) compared with those who did not. LTPA was associated with reduced odds of having hormone receptor-positive by 41% and significantly associated with reduced odds of having triple-negative breast cancer by 45%. In addition, a significant dose-response relationship was observed, women with higher levels of LTPA had lower odds of having overall breast cancer as well as having triple-negative and hormone receptor-positive breast cancer. Conclusions Increasing LTPA in African women can play a significant role in reducing the incidence of breast cancer, particularly of the more aggressive subtype as triple-negative, which is more prevalent in Sub-Saharan Africa.

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Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms

2020

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An estimated 4 in 10 cancers are preventable through modifiable risk factors. This review summarizes the epidemiologic evidence linking physical activity, sedentary behavior, and obesity with cancer risk. We explore the possible biologic mechanisms underpinning the associations between these lifestyle factors and cancer incidence, including effects on endogenous sex steroids and metabolic hormones, insulin sensitivity, and chronic inflammation.

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The Mechanisms and Effects of Physical Activity on Breast Cancer

Cited by 102 publications

References 66 publications

Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

Aerobic capacity correlates with health‐related quality of life after breast cancer surgery

Leisure-Time Physical Activity is Associated with reduced Risk of Breast Cancer and Triple Negative Breast Cancer in Nigerian Women: a matched case-control study

Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms

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