The Mechanisms and Causes of Sudden Cardiac DEATH.FACTORS and Risk Stratification in Clinical Practice. Definitions and Terms

Aim. To assess the role of stimulating growth factor 2 (ST-2) and galectin-3 in predicting the ventricular tachyarrhythmias (VTA) in patients with coronary artery disease (CAD) and left ventricular ejection fraction (LVEF) <35%.Material and methods. The study included 40 patients (men, 36 (90,0%); median age, 64,5 [57,5; 68,5] years) with CAD, NYHA class IIIII heart failure, LVEF <35%, indications for implantable cardioverter defibrillator (ICD) (primary prevention of sudden cardiac death). Prior to ICD implantation, patients were measured for serum ST-2 and galectin-3 levels. For 18 months, patients were assessed for arrhythmic events recorded in the ICD memory.Results. The 1st group consisted of 10 (25,0%) patients who had VTA episodes, arrested by antitachycardia pacing or shock during 18-month follow-up. The 2nd group consisted of 30 (75,0%) patients without VTA episodes. It was found that ST-2 concentration >22,48 ng/ml (p=0,02) and galectin-3 >10,95 ng/ml (p=0,009) corresponded to appropriate ICD discharge. Multivariate ROC analysis demonstrated that the only independent predictor of VTA was ST-2 elevation (odds ratio, 1,11; 95% CI, 1,01-1,21; p=0,023).Conclusion. An increase in the concentration of both ST-2 >22,48 ng/ml and galectin-3 >10,95 ng/ml had a high predictive value in assessing the VTA risk in patients with ischemic cardiomyopathy. In multivariate analysis, an increase in ST-2 >22,48 ng/ml was an independent predictor of VTA.

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Role of stimulating growth factor 2 and galectin-3 in predicting the ventricular tachyarrhythmias in patients with ischemic cardiomyopathy

Atabekov

Баталов

Сазонова

et al. 2021

Cardiovasc Ther Prev

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Important aspects of the development of the children’s cardiological services of the Grodno region. Analysis of sixty years of activity

Томчик

Парамонова

2021

Medicinskij sovet

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Introduction. The relatively young science of pediatric cardiology has made enormous breakthroughs in recent years: the labor intensity and complexity of modern diagnostic techniques have increased, and interventional methods of treatment are widely used. Modern pediatric cardiology covers a wide range of diseases: from intrauterine pathology, such as congenital heart and vascular defects, fibroelastosis, various arrhythmias, to acquired diseases represented by arterial hyperand hypotension, systemic vasculitis, autonomic dysfunction, juvenile rheumatoid arthritis.Purpose. To demonstrate the important stages of the development of the children’s cardiological service in Grodno region over a sixty-year period, assess its current state and analyze the dynamics of the incidence rate of children’s heart and vascular diseases during 2005–2019 in this region.Material and methods. During the period of 1960–2019 a retrospective research was carried out using the statistics: report of the chief substitute pediatric cardiologist, report of medical treatment for children during 2005–2019, analytical and conjunctral reports, reviews and references of chief doctors and local pediatricians.Results and discussion. The sixty-years of activity of the children’s cardiological service in Grodno region were analyzed. It was found that over the past 15 years there has been an annual increase in the overall incidence of diseases of the circulatory system (classes I00-I99 ICD 10), while the primary incidence decreased from 331.06 to 265.63 per 100,000 of the child population. The overall incidence of congenital heart defects over the past 15 years was characterized by a low decrease from 916.40 to 800.16 cases against the stabilization of the primary incidence rate.Conclusion. The obtained results indicate the well-organized work of the diagnostic, hospital, dispensary and prophylactic stages of medical assistance to children with cardiovascular pathology.

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The Mechanisms and Causes of Sudden Cardiac DEATH.FACTORS and Risk Stratification in Clinical Practice. Definitions and Terms

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Role of stimulating growth factor 2 and galectin-3 in predicting the ventricular tachyarrhythmias in patients with ischemic cardiomyopathy

Role of stimulating growth factor 2 and galectin-3 in predicting the ventricular tachyarrhythmias in patients with ischemic cardiomyopathy

Important aspects of the development of the children’s cardiological services of the Grodno region. Analysis of sixty years of activity

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