Abstract:Fluoro-deoxyuridine monophosphate (FdUMP) is an active metabolite of 5-fluorouracil (5-FU) synthesized through two hypothesized pathways: The orotate phosphoribosyl transferase-ribonucleotide reductase (OPRT-RR) pathway and the thymidine phosphorylase-thymidine kinase (TP-TK) pathway. In the present study, the mechanism underlying 5-FU resistance was investigated, focusing on changes in 5-FU metabolism using MCF-7, 5-FU-resistant MCF-7/5-FUR, MDA-MB-231 and 5-FU-resistant MDA-MB-231/5-FUR breast cancer cells. … Show more
“…In addition, the carrier solvent (0.1% DMSO) was used for control cells. The 5-Fluorouracil was used as positive control for the three cancer cell lines with a concentration 140.0 μmol mL −1 , 36 1.1 μmol mL −1 , 37 and 125 μg mL −1 , 38 on MCF7, HepG2, and HCT116; respectively. Cells were maintained at 37 °C in an atmosphere of 5% CO 2 for 48 hours.…”
2-Aminobenzothiazole derivatives, have attracted interest for their versatility in generating novel anticancer agents. This study explores the synthesis, and anticancer evaluation of new pyrimidine-based 2-aminobenzothiazole derivatives.
“…In addition, the carrier solvent (0.1% DMSO) was used for control cells. The 5-Fluorouracil was used as positive control for the three cancer cell lines with a concentration 140.0 μmol mL −1 , 36 1.1 μmol mL −1 , 37 and 125 μg mL −1 , 38 on MCF7, HepG2, and HCT116; respectively. Cells were maintained at 37 °C in an atmosphere of 5% CO 2 for 48 hours.…”
2-Aminobenzothiazole derivatives, have attracted interest for their versatility in generating novel anticancer agents. This study explores the synthesis, and anticancer evaluation of new pyrimidine-based 2-aminobenzothiazole derivatives.
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