The Mechanism of the Davy Test for Strychnine

Sánchez‐Viesca, Francisco; Gómez, Reina

doi:10.9734/irjpac/2022/v23i130438

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…In this communication the electron flow is given in each step of the series of reactions that take place during this colour test. This paper is a follow up of our studies on reaction mechanism, [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 90%

On the chemistry of the Archetti test for caffeine and uric acid

Sánchez-Viesca¹,

Gómez²

2023

World J. Chem. Pharm. Sci.

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The Archetti colour test is based on the reduction of ferricyanide ions to ferrocyanide, giving Prussian blue. However, the oxidation sequence of reactions that take in the organic molecule has not been described. Some electroanalytical experiments on the oxidation of caffeine have been done but the results have not been adequately interpreted. Besides, they are incomplete since only the redox reactions can be detected, but not the isomerization and degradation path. In the present communication the complete oxidation route of caffeine is given, as well as the electron flow in each step. It involves hydration of the imino group and oxidation to 1,3,7-trimethyl-uric acid, formation of radical ion at C-9, interaction with the C─C double bond, aziridinone formation, carbon monoxide extrusion, carbonium ion neutralization, imine acidolysis, isomerization of carbinolamine and hydrolysis to the end products.

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Section: Introductionmentioning

confidence: 90%

On the chemistry of the Archetti test for caffeine and uric acid

Sánchez-Viesca¹,

Gómez²

2023

World J. Chem. Pharm. Sci.

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“…This compound is p-phenetolcarbamide, Figure 1. This paper is a follow up of our studies on reaction mechanism, [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 90%

On Dulcin detection by electron transfer

Viesca¹,

Gómez²

2023

World J. Chem. Pharm. Sci.

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The artificial sweetener Dulcin has been detected by reaction with mercury nitrate (Jorissen test), with silver nitrate or with mercury chloride (Ruggeri test). With these reagents a violet colour is developed. Since there are few violet organic compounds, and these exhibit structures more complex than the expected one from Dulcin, it was pertinent direct the attention in order to clear up the chemistry involved in these assays. The reagents employed have reducible cations; thus, there must be oxidations via electron transfer. However, the Dulcin molecule does not show an adequate site for this type of reaction. Nevertheless, hydrolysis of the ureido chain in Dulcin gives 1,4-phenetidine which is suitable for electron transfer. This way organic radical cations similar to the violet Wurster’s salts can be formed. These compounds are in resonance with quinonoid structures. The sui generis hydrolysis of the ureido chain is commented. This reaction and the degradation of the companion isocyanic acid occur via zwitterions.

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“…It is important and interesting to know what is happening during the test, not only its application. This communication is a follow up of our studies on reaction mechanism, [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Organometallic intermediates in Böttger test for glucose in urine

Francisco Sánchez Viesca,

Reina Gómez Gómez

2023

Magna Sci. Adv. Res. Rev.

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The reaction mechanism in organometallic chemistry is not always correctly understood or it is missing. In this communication the reaction route in the Böttger test for glucose is provided. The reagent can be bismuth subnitrate or bismuth meta-hydroxide (also called hydrated oxide of bismuth), since in alkaline medium (sodium carbonate) the nitrate ion is displaced by hydroxyl. The basic medium is essential in order to activate the glucose molecule. The reaction goes through a series of organometallic intermediates in a redox process. Finally, elemental bismuth separation occurs via one electron transfer in a bimolecular reaction. The white insoluble solid formed in situ blackens since it is covered by metallic bismuth.

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The Mechanism of the Davy Test for Strychnine

Cited by 9 publications

References 7 publications

On the chemistry of the Archetti test for caffeine and uric acid

On the chemistry of the Archetti test for caffeine and uric acid

On Dulcin detection by electron transfer

Organometallic intermediates in Böttger test for glucose in urine

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