The mechanism of the biologic activity of a series of nitroolefins

Synthesis and Crystal Structure of trans-2-(2,4,6-Trimethylphenyl)-1-Nitroethylene

“…The crystal of (I) with dimensions of 0.40 mm × 0.12 mm × 0.10 mm was mounted on a Rigaku Saturn CCD area-detector diffractometer with a graphite-monochromated MoKα radiation (λ = 0.71073 Å) by using a phi and scan modes at 113(2) K in the range of 1.35º ≤ θ ≤ 25.02º. The crystal belongs to triclinic system with space group P-1 and crystal parameters of a = 9.700 5 3 . The absorption coefficient µ = 0.087 mm -1 and Z = 4.…”

“…The nitroalkene compounds are commonly synthesized by the dehydration of β-nitroalcohols that are in situ prepared by Henry reaction of various aldehydes with a nitroalkane in a basic condition, in which the dehydration of β-nitroalcohols are achieved by a transformation of the hydroxyl group into a good leaving group or simply by heating in an acidic condition 1,2 . Particularly, the aromatic nitroalkene compounds have been proved to be a significant class of the nitroalkenes, which possess diverse biological activities such as mollusicicidal activities 3,4 , insecticidal activities 4 , antimicrobial activities 5,6 , anticancer activities 7 and anti HVI-1 activities 8 etc. Detailed study on the synthesis and structures of such compounds seems very important to better understand the relationship between molecular structures and biological activities.…”

Kinetics of the reaction of the first metabolite of fenitropan with some low molecular weight thiols

“…log kRs-= -2.559+ 1.049 pK, r = 0.957 ( 5 ) This relationship shows a negative correlation between the reactivity of thiolate anions and the dissociation extent of thiols at the given pH value.…”