The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats

Naderali, Ebrahim K.; SMITH, Sharon L.; DOYLE, Patrick J.; Williams, Gareth

doi:10.1042/cs20000123

Cited by 25 publications

(20 citation statements)

References 34 publications

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“…To assess the endothelial integrity of the preparation, we used acetylcholine (20 μM). Failure of arteries to relax to acetylcholine was considered to indicate a state of endothelial denudation (22).…”

Section: Assessment Of Vascular Functionmentioning

confidence: 99%

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A Role of Ion Channels in the Endothelium-Independent Relaxation of Rat Mesenteric Artery Induced by Resveratrol

et al. 2008

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Abstract.Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced concentration-dependent relaxation of rat mesenteric artery. Among the K + -channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibenclamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K + , the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence of K + channels and voltage-gated Ca 2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 mM K + in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K + channels. Its ability to completely relax the mesenteric artery precontracted with K + -rich solution suggests that K + channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K + channel-independent effect of resveratrol.

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Section: Assessment Of Vascular Functionmentioning

confidence: 99%

“…The resveratrol-induced vasorelaxation may either be endothelium-dependent (attenuated by L-NAME) or endothelium-independent (6,7,10). The mechanism of endothelium-independent vasorelaxation induced by resveratrol is uncertain.…”

Section: Introductionmentioning

confidence: 99%

A Role of Ion Channels in the Endothelium-Independent Relaxation of Rat Mesenteric Artery Induced by Resveratrol

et al. 2008

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“…To assess the endothelial integrity of the preparation we have used acetylcholine (20 µM). Failure of arteries to relax to acetylcholine was considered to indicate a state of endothelial denudation (6).…”

Section: Assessment Of Vascular Functionmentioning

confidence: 99%

The Mechanism of Endothelium-Independent Relaxation Induced by the Wine Polyphenol Resveratrol in Human Internal Mammary Artery

et al. 2006

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Abstract. Resveratrol, a stilbene polyphenol found in grapes and red wine, produces vasorelaxation in both endothelium-dependent and endothelium-independent manners. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of endothelium-independent resveratrol-induced vasorelaxation in human internal mammary artery (HIMA) obtained from male patients undergoing coronary artery bypass surgery and to clarify the contribution of different K + channel subtypes in resveratrol action in this blood vessel. HIMA rings without endothelium were precontracted with phenylephrine. Resveratrol induced a concentration-dependent relaxation of the HIMA. A highly selective blocker of ATP-sensitive K + channels, glibenclamide, as well as nonselective blockers of Ca 2+ -sensitive K + channels, tetraethylammonium and charybdotoxin, did not block resveratrolinduced relaxation of HIMA rings. 4-Aminopyridine (4-AP), non selective blocker of voltagegated K + (K V ) channels, and margatoxin that inhibits K V 1.2, K V 1.3, and K V 1.6 channels abolished relaxation of HIMA rings induced by resveratrol. In conclusion, we have shown that resveratrol potently relaxed HIMA rings with denuded endothelium. It seems that 4-AP-and margatoxinsensitive K + channels located in smooth muscle of HIMA mediated this relaxation.

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“…It has been shown that resveratrol exhibits the estrogenic [30], antioxidant [31], antiviral [32], antiplatelet [33], anti-thyroid [34] and cancer chemopreventive activity [35]. Furthermore, resveratrol enhances the expression and activity of endothelial nitric oxide synthase [36] and induces vasorelaxation [37]. Resveratrol has the inhibitory effect on enzyme α-glucosidase which can be a potential mechanism of its antidiabetic activity [38].…”

Section: Resorcinol Derivativesmentioning

confidence: 99%

Classification and biological activity of phytoestrogens: A review

Nikolic¹,

Gajić²,

Tacic³

et al. 2017

Adv Techol

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Phytoestrogens represent polyphenolic and non-steroid compounds that have a similar structure and biological activity as human estrogens. They are the plant secondary metabolites and widespread in over 300 various plant species. The phytoestrogens are divided into two main subgroups, isoflavonoids and lignans. The isoflavonoids are divided into isoflavones and coumestans. Isoflavones are most present in soybean and red clover. A great number of isoflavones has been identified in the plants in the form of non-active glycosides (daidzein and genistein) and in the form of 4'-methylated derivatives (formononetin and biochanin A). Coumestans can also be found in red clover and legumes, while lignans are most present in the flax seed. Coumestans have the most pronounced estrogenic effect of all phytoestrogens. The most famous representative of this subgroup of compounds is coumestrol. Lignans include matairesinol, secoisolariciresinol, lariciresinol, pinoresinol and their metabolites, enterodiol, enterolactone and equol. Numerous studies in animals and humans have shown that phytoestrogens can have protective effects in the estrogen-dependent conditions and estrogen-dependent diseases. It was also shown that the use of phytoestrogens can have a positive effect on insomnia and cognitive functions, i.e. neural disorders, such as Alzheimer's disease. They can express the antioxidant activity in two ways, as the scavengers of free radicals or by the formation of chelating complexes with metal ions. Free metal ions increase the amount of reactive oxygen species by reduction of hydrogen peroxide resulting in a very reactive hydroxyl radical.

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The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats

Cited by 25 publications

References 34 publications

A Role of Ion Channels in the Endothelium-Independent Relaxation of Rat Mesenteric Artery Induced by Resveratrol

A Role of Ion Channels in the Endothelium-Independent Relaxation of Rat Mesenteric Artery Induced by Resveratrol

The Mechanism of Endothelium-Independent Relaxation Induced by the Wine Polyphenol Resveratrol in Human Internal Mammary Artery

Classification and biological activity of phytoestrogens: A review

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