The Mechanism of Injury in a Steatotic Liver Graft during Cold Preservation

Fukumori, Tatsuya; Ohkohchi, Nobuhiro; Tukamoto, Sigeki; Satomi, Susumu

doi:10.1097/00007890-199810270-00066

Cited by 39 publications

(58 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is believed to be caused by the accumulation of nonesterified fatty acids and has been postulated as a possible mechanism for the increased sensitivity of fatty livers to ischemic injury. 32 Some postulate that the critical injury is to the sinusoidal lining cell, with an alteration in plasma membrane fluidity 33 and subsequent blood cell adhesion and Kupffer's cell activation. 28 Others suggest that fat-laden hepatocytes undergo changes, including solidification during cold injury, and are responsible for increased sensitivity to reperfusion injury, releasing fatty globules that can disrupt the sinusoid microcirculation.…”

Section: Mechanisms Linking Fatty Change To Pnfmentioning

confidence: 99%

Hepatic steatosis and its relationship to transplantation

Imber

Peter

Handa

et al. 2002

Liver Transplantation

149

108

View full text Add to dashboard Cite

Section: Mechanisms Linking Fatty Change To Pnfmentioning

confidence: 99%

Hepatic steatosis and its relationship to transplantation

Imber

Peter

Handa

et al. 2002

Liver Transplantation

149

108

View full text Add to dashboard Cite

“…It has been suggested that steatosis may cause hepatic dysfunction by altering cell membrane fluidity or disrupting the microcirculation. [24][25][26] Acceptable amount of steatosis. There currently is no widely agreed on percentage of steatosis that serves as a cutoff value for safe performance of LDLT.…”

Section: Steatosismentioning

confidence: 99%

Evaluation of the donor liver for living donor liver transplantation

Brandhagen

Fidler

Rosen

2003

Liver Transplantation

View full text Add to dashboard Cite

“…[65][66][67] The combination of steatosis and cold ischemia results in reversible (usually) graft dysfunction, presumably caused by microcirculatory disturbances and alterations of the cell membrane. 68 Livers from living donors are not subjected to significant cold ischemia, and the contribution of steatosis to graft dysfunction should therefore be minimal. The results of several series support this hypothesis.…”

Section: Steatosis In Graftsmentioning

confidence: 99%

Right lobe living donor liver transplantation: A review

Marcos

2000

Liver Transpl

157

View full text Add to dashboard Cite

The continuing shortage of organs for adult transplant recipients has generated enthusiasm for adult-to-adult living donor liver transplantation (LDLT). The major concern has been the ability to resect a graft of adequate size without subjecting the donor to undue risk. The right hepatic lobe is generally large enough for adult recipients, but because of the real and perceived risks of right lobe (RL) resection, surgeons have been hesitant to offer this option to their patients. The first series of RL resections that included a significant number of patients was reported in 1999, and the results were encouraging. Only minor complications occurred in donors, and the recipients fared quite well. Enthusiasm for these donor resections is growing, and more centers are beginning to perform them. There is a good deal of global experience with pediatric LDLT but little with adults, and there are unique considerations in this population. This review examines donor selection criteria for adult recipients, highlights technical points critical for good outcome, and examines the early results and complications in both donors and recipients. If the preliminary results continue to be reproduced, RL LDLT could have significant impact on the worsening organ shortage.

show abstract

The Mechanism of Injury in a Steatotic Liver Graft during Cold Preservation

Cited by 39 publications

References 0 publications

Hepatic steatosis and its relationship to transplantation

Hepatic steatosis and its relationship to transplantation

Evaluation of the donor liver for living donor liver transplantation

Right lobe living donor liver transplantation: A review

Contact Info

Product

Resources

About