The mechanism of inflammation

McGovern, V. J.

doi:10.1002/path.1700730113

Cited by 38 publications

(9 citation statements)

References 3 publications

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“…Anti-inflammatory actions of heparin have also been described. For example, it has been shown to suppress neutrophil function and chemotaxis in vitro (Matzner et al, 1984;Bazzoni et al, 1993), reduce neutrophil migration into the inflamed rat paw (McGovern, 1957) and inhibit increases in vascular permeability in rabbit skin (Lecomte & Hugues, 1954;Carr, 1979). Heparin also appears to diminish the bronchoconstrictor response of sheep to allergic and nonallergic stimuli (Ahmed et al, 1992) and the immediate response to antigen in the skin and lungs of allergic human subjects (Bowler et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

Teixeira

Hellewell

1993

British J Pharmacology

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1 Heparin is widely used in the treatment of thrombotic disorders and as an aid in surgery. Antiinflammatory effects of heparin have also been described. In this study, we have investigated the effects of locally-injected heparin on the oedema formation and eosinophil accumulation induced by various inflammatory stimuli in guinea-pig skin.2 Heparin dose-dependently suppressed the accumulation of "'In-labelled eosinosphils induced by i.d. injection of zymosan-activated plasma (ZAP). The "'In-eosinophil accumulation induced by other inflammatory stimuli (compound 48/80, platelet activating factor, interleukin-8 and in a passive cutaneous anaphylaxis reaction) was also suppressed by locally-injected heparin. 3 Oedema formation in response to these same stimuli was not altered by the local injection of heparin. 4 Fucoidin, a negatively-charged sulphated algal polymer, had no effect on the "1'In-eosinophil accumulation or oedema formation induced by ZAP. Nevertheless, fucoidin significantly suppressed the oedema formation induced by i.d. injection of cationic protein-containing extracts of Schistosoma mansoni larvae. Heparin also inhibited oedema induced by the extracts, suggesting that both fucoidin and heparin were effectively neutralizing the cationic protein of the extracts to inhibit their oedemainducing activity.5 Thus, heparin significantly inhibited the accumulation of "'In-eosinophils, but not oedema formation, induced by various inflammatory stimuli. This, taken together with the lack of effect of fucoidin, suggests that heparin interferes with the process of eosinophil trafficking by a mechanism that does not depend on neutralisation of the charge of the stimulatory molecules.

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Section: Introductionmentioning

confidence: 99%

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

Teixeira

Hellewell

1993

British J Pharmacology

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“…The high power density present for a fraction of a millisecond within a diameter of a few microns, suggests itself as a means for producing a highly localized injury to a selected target tissue.12. l 3 The target tissue chosen in the present study was the microvasculature of the exteriorised rat meso-appendix preparation. The relative transparency of this preparation permits precise focusing of the laser beam and the production of discrete lesions on the inner surface of selected blood vessels without the induction of hemorrhage or apparent injury to surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

LASER‐INDUCED MICROVASCULAR THROMBOSIS, EMBOLIZATION, AND RECANALIZATION IN THE RAT^*

Kochen

Baez

1965

Annals of the New York Academy of Sciences

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A well known characteristic of the early phase of inflammation is the adherence of white cells in the blood to the endothelium of the blood vessels. The mechanism of this sticking of the cells is not understood.It has been claimed that heparin can modify the process (Zweifach, 1954 ; Allison, Smith and Wood, 1955 ;McGovern, 1957), but more recently Lancaster (1960, 1961) have denied this. If it is true that heparin reduces white cell sticking this may mean that intermediates in the blood clotting mechanism are responsible for the sticking.

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confidence: 99%

“…It has been claimed that heparin can modify the process (Zweifach, 1954 ; Allison, Smith and Wood, 1955 ;McGovern, 1957), but more recently Lancaster (1960, 1961) have denied this. If it is true that heparin reduces white cell sticking this may mean that intermediates in the blood clotting mechanism are responsible for the sticking.…”

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confidence: 99%

The effect of heparin on the sticking of white cells to endothelium in inflammation

1962

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Thyagarajan, T. R. (Cornell University, Ithaca, N. Y.) and H. B. Naylor. Cytology of Rhodotorula glutinis. J. Bacteriol. 83:127-136. 1962.-The structure and manner of division of nuclei in actively dividing cells of Rhodotorula glutinis were studied with the phase contrast microscope. The nucleus consists of a dense central body, surrounded by a shell of optically uniform material of low density. The entire structure is enclosed within a nuclear membrane. Various fixation and staining techniques were employed to confirm the observations made from living cells. Since the dense central body is Feulgen-negative and is readily stained by iron alum hematoxylin, it is identified as the nucleolus. The material surrounding the nucleolus has no marked affinity for hematoxylin but is Feulgen-positive and stains intensely with Giemsa and basic fuchsin. The nucleus appears to divide by a process of elongation and constriction during which roughly half of the nucleolus, along with the surrounding chromatin, passes into the bud. The nuclear membrane was found to persist during all stages of division. Vacuoles were seldom observed in actively dividing cells. The nucleus of R. glutinis is similar in structure to the nuclei of higher organisms, but its behavior during division is quite different.

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The mechanism of inflammation

Cited by 38 publications

References 3 publications

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

LASER‐INDUCED MICROVASCULAR THROMBOSIS, EMBOLIZATION, AND RECANALIZATION IN THE RAT^*

The effect of heparin on the sticking of white cells to endothelium in inflammation

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The mechanism of inflammation

Cited by 38 publications

References 3 publications

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

LASER‐INDUCED MICROVASCULAR THROMBOSIS, EMBOLIZATION, AND RECANALIZATION IN THE RAT*

The effect of heparin on the sticking of white cells to endothelium in inflammation

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LASER‐INDUCED MICROVASCULAR THROMBOSIS, EMBOLIZATION, AND RECANALIZATION IN THE RAT^*