The mechanism of hypoproteinemia in patients with regional enteritis and ulcerative colitis

Steinfeld, Jesse L.; Davidson, John D.; Gordon, Robert; Greene, Frank E.

doi:10.1016/0002-9343(60)90036-x

Cited by 136 publications

(33 citation statements)

References 24 publications

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“…Serum CRP is an acute-phase reactant that increases when in flammation is present and reflects the amount of tissue damage [18]. Thus, in UC, the CRP level may reflect the extent of the lesions [7], Patients with malnutrition had a worse clinical response in the acute phase, perhaps because of loss of protein into the intestinal tract [19]; nutritional status may reflect the extent and severity of mucosal inflamma tory changes. Serum ChE activity decreases in liver disorders, such as acute hepatitis or cirrhosis, and also in malnutrition and hy pothyroidism [20].…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors for the Response of Ulcerative Colitis Patients during the Acute-Phase Treatment

et al. 1990

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Twenty-six consecutive admissions of 24 patients with severe ulcerative colitis (UC) hospitalized in our Department at some time between January 1983 and December 1988 were studied to identify factors useful in the prediction of response to medical treatment in the acute inflammatory phase of this disease. Results of laboratory tests (white blood cells, red blood cells, platelet count, hemoglobin, erythrocyte sedimentation rate, total protein, albumin, α₂-microglobulin, cholinesterase, total cholesterol, and triglycerides) and of endoscopic findings (extent of disease, progress of the lesions, sparing of the rectum, and presence of geographic ulcers, longitudinal ulcers, and polypoid mucosal tags) were analyzed for any relationship with the effect of medical treatment during the acute phase. The effect of treatment was evaluated in terms of days it took for a severe condition to improve to an intermediate one defined by Truelove and Witts’ categories for UC severity. C-Reactive protein, nutritive condition (total protein, albumin, and cholinesterase), extent of the lesions, and existence of polypoid mucosal tags provide predictive factors useful in the management of UC during the acute phase.

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Section: Discussionmentioning

confidence: 99%

Predictive Factors for the Response of Ulcerative Colitis Patients during the Acute-Phase Treatment

et al. 1990

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“…It has been proposed th at a distinction should be made between prim ary and secondary exudative enteropathies [4], The latter are found in a great m any gastro-intestinal diseases including hypertro phic gastritis with giant rugae [3], neoplasies of the stomach [5,12], idiopathic steatorrhea [10,14], W hipple's disease, acute gastroente ritis [10,16], megacolon, ulcerative colitis, regional enteritis [14], intestinal lymphoma [10]. By a different mechanism, an exudative enteropathy occurs in constrictive pericarditis and in congestive heart failure [8].…”

Section: Discussionmentioning

confidence: 99%

Protein-Losing Enteropathy. Report of Case and Isotope Studies

Brunetti¹,

Puxeddu²,

Palumbo³

et al. 1965

Digestion

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“…Plasma volume, total albumin turnover, and total exchangeable albumin (TEA) were calculated from the 'I data by a modification of the methods of Berson, Yalow, Schreiber, and Post (15) and Steinfeld, Davidson, Gordon, and Greene (16).…”

Section: Calculationsmentioning

confidence: 99%

Use of 125I- and 51Cr-Labeled Albumin for the Measurement of Gastrointestinal and Total Albumin Catabolism*

Kerr¹,

Bois²,

Holt³

1967

J. Clin. Invest.

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Abstract. A method for the simultaneous measurement of gastrointestinal protein loss and total albumin turnover entailing the use of a combination of 125iodine-and 51chromium-labeled albumin is described. Albumin turnover was calculated by the measurement of albumin-125I plasma decay and cumulative urinary excretion, and the results obtained agreed closely with previous studies utilizing albumin-'31I. Gastrointestinal catabolism was calculated from the rate of fecal excretion of 51Cr and the specific activity of plasma albumin-51Cr, and these data were related to the calculated albumin turnover results. During the period of 6-14 days after administration, the ratio of specific activties of albumin-125I and -51Cr in plasma and in extravascular spaces or gastric and biliary secretions remained almost identical. Fecal excretion of 51Cr was also quite stable at this time. In six normal subjects gastrointestinal catabolism accounted for less than 10% of total albumin catabolism. Excessive gastrointestinal protein losses did not contribute to the low serum albumin in three patients with cirrhosis or in two adults with the nephrotic syndrome. Multiple mechanisms leading to hypoalbuminemia were demonstrated in other subjects with a variety of gastrointestinal disorders.

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The mechanism of hypoproteinemia in patients with regional enteritis and ulcerative colitis

Cited by 136 publications

References 24 publications

Predictive Factors for the Response of Ulcerative Colitis Patients during the Acute-Phase Treatment

Predictive Factors for the Response of Ulcerative Colitis Patients during the Acute-Phase Treatment

Protein-Losing Enteropathy. Report of Case and Isotope Studies

Use of 125I- and 51Cr-Labeled Albumin for the Measurement of Gastrointestinal and Total Albumin Catabolism*

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