The mechanism of ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating the TRP ion channel-mediated ERK_1/2/NF-κB signaling pathway

Abstract

Mechanism of Ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating the TRP ion channel-mediated ERK1/2/NF-κB signaling pathway.

Metabolomics study of graphene nuangong acupoint plaster for primary dysmenorrhea

“…Additionally, Sichuan pepper [ 29 , 30 ], mugwort leaf [ 31 , 32 ], and Cyperus rotundus [ 33 ] contain volatile oils and their main constituents, which exhibit anti-inflammatory, antioxidant, and analgesic effects. Dried ginger can improve the pathological condition of the uterus in a Parkinson's disease rat model by modulating the ERK1/2/NF-κB signaling pathway mediated by transient receptor potential (TRP) ion channels [ 34 ]. In summary, the pharmaceutical ingredients of GNGAP possess analgesic and anti-inflammatory properties, providing assurance for the treatment of PD.…”

Mechanism of action of Taohong Siwu decoction in the alleviation of primary dysmenorrhea

“…Sixty rats were randomly divided into the following 6 groups (n = 10 per group) after 1 week of adaptive feeding: the normal control group (NC); the model control group (MC); the positive control group (PC: TJB, 2.1 g/kg); the low-dose TSD group (TSD-L: 4.5 g/kg); the medium-dose TSD group (TSD-M: 9.0 g/kg); and the high-dose TSD group (TSD-H: 13.5 g/kg). The PD model of rats was established according to previous research ( 24 ). Except for rats in the NC group, rats in the other groups received intragastric administration of EB (0.4 mg/kg, the first and last day doses were double) once daily for 12 consecutive days, and the rats were couple-stimulated using an IWM (0–4°C) administered to the lower abdomen once daily (20 min per time) to establish the model of PD with CCBS.…”