The mechanism of corpuscle and serum anaphylaxis in the rabbit

Abstract

The mechanism of corpuscle and serum anaphylaxis in the rabbit. By ARTHUR F. COCA.

Elements of the history of our present concepts of anaphylaxis, hay fever and asthma

“…He noted the pronounced dilation of the right heart and he attributed this to cardiac failure. Coca in 1919 [46], and Drinker and Bronfenbrenner in 1924, observed an increase in pulmonary arterial pressure in the rabbit beginning within 30 seconds of antigenic challenge. Coca observed a greatly increased resistance to perfusion of saline through the pulmonary artery during anaphylaxis in rabbits and inferred that the right heart dilatation was secondary to the '.…”

Sur les réactions allergiques de type immédiat (Part 2 of 2)

“…A l'autopsie, congestion importante des viscères abdominaux et de la circulation de retour: turgescence du coeur droit et de l'artère pulmonaire, traduisant la présence d'un obstacle à la pro gression du sang dans la petite circulation (Coca, 1919). c) Asphyxie par bronchospasme: cobaye Le choc anaphylactique se caractérise par l'apparition rapide d'une dyspnée de type expiratoire, qui entraîne l'asphyxie.…”