Abstract:Alzheimer’s disease (AD) is a dementia-related disease with cognitive deterioration and memory impairment. Catalpol was reported to relieve impairments in learning and memory. The present study assessed the functional mechanism of catalpol in AD via miR-124/STIM2-mediated mitochondrial function. Primary hippocampal neurons were isolated and cultured. AD cell model was induced by Aβ1−42 and treated with catalpol. APP/PS1 mouse model was established and treated with catalpol and miR-124 agomir. Aβ1−42 induced mi… Show more
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