The mechanism of carvacrol-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in OC2 human oral cancer cells

Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells

“…As shown in Figure 2A and B, the cell viability and colony formation ability of A549 and H460 NSCLC cells were reduced by carvacrol in a dose-dependent manner. This was consistent with many earlier reports showing the antiproliferative effect of carvacrol in breast cancer (35), colon cancer (36), gastric adenocarcinoma (37), glioblastoma, hepatocellular carcinoma (38), NSCLC (39), oral cancer (40), and prostate cancer (33). Interestingly, the inhibitory effect of carvacrol on cell viability and colony formation was attenuated by ectopic expression of AXL ( Figure 2D and E), indicating that carvacrol down-regulates AXL expression to result in the inhibition of cell proliferation.…”

Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: Involvement of MEK–ERK activation

“…In human cancer, antiproliferative and cytotoxic properties of carvacrol have been demonstrated in lymphoma (Bhakkiyalakshmi et al, ), colon cancer (Fan et al, ), glioblastoma (Chen et al, ; Liang & Lu, ), hepatoma (Melušová, Jantová, & Horváthová, ), neuroblastoma (Aydın, Türkez, & Keleş, ), oral cancer (Liang et al, ), cervical cancer (Mehdi, Ahmad, Irshad, Manzoor, & Rizvi, ), metastatic breast cancer (Arunasree, ), chronic myeloid leukemia (Horvathova, Turcaniova, & Slamenova, ), leiomyosarcoma (Karkabounas et al, ), nonsmall cell lung cancer (Koparal & Zeytinoglu, ), and melanoma cells (He, Mo, Hadisusilo, Qureshi, & Elson, ), which are mainly attributed to reactive oxygen species‐mediated apoptosis. However, the mechanism of carvacrol‐induced cancer cell cytotoxicity has not been elucidated, neither the possibility of a drug–phytochemical interaction.…”

Carvacrol exhibits anti-oxidant and anti-inflammatory effects against 1, 2-dimethyl hydrazine plus dextran sodium sulfate induced inflammation associated carcinogenicity in the colon of Fischer 344 rats

“…Carvacrol has been reported with many pharmacological potential such as anti-oxidant [15], anti-inflammatory [16] and anti-tumor [17], anti-carcinogenic [18] and anti-cancer properties [19,20]. Till now, there are no reports available on the possible anti-antioxidant as well as anti-inflammatory effect of carvacrol.…”