The mechanism of bone metabolism in a Sprague Dawley rat model of mandibular osteoradionecrosis
Shanshan Liu,
Bin Zhang,
Shengnan Ma
et al.
Abstract:Background
Osteoradionecrosis (ORN) is a serious complication of radiotherapy for head and neck cancer. There is currently a lack of data on the dynamic expression of genes related to bone remodeling during the development of mandibular ORN. This study aimed to establish an animal model of ORN in Sprague Dawley (SD) rats, detect the expression of genes related to bone metabolism, observe morphological changes, and clarify the mechanism of ORN.
Methods
A total of 24 male… Show more
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