The Mechanism of Action of Erythropoietin: Erythroid Cell Response

Spivak, Jerry L.

doi:10.1007/978-3-642-75865-2_4

Cited by 6 publications

(1 citation statement)

References 398 publications

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“…Erythropoietin is the principal humoral regulator of erythropoiesis and acts by simulating the differentiation and proliferation of erythroid progenitor cells in the bone marrow (Spivak, 1986). In adult mammals the primary source of erythropoietin is the kidney (Jacobson et al, 1057) but the precise cellular origin of this hormone remains controversial despite the cloning of erythropoietin genes in man, monkey and mouse (Jacobs et al, 1985;Lin et al, 1985Lin et al, , 1986McDonaldet al, 1986;Shoemaker & Mitsock, 1986).…”

mentioning

confidence: 99%

Erythropoietin production in kidney tubular cells

Maxwell¹,

Lappin²,

Johnston³

et al. 1990

Br J Haematol

114

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The erythropoietin gene has been cloned in three mammalian species including man and recombinant erythropoietin is now used to treat the anaemia of chronic renal failure. Despite the isolation of the gene the precise cellular location of erythropoietin synthesis remains controversial. We present studies which demonstrate erythropoietin production by kidney tubular cells. Erythropoietin gene expression (messenger RNA) was detected by in situ hybridization using an oligonucleotide gene probe and the translated protein product by immunohistochemistry employing antibodies raised to pure recombinant DNA derived erythropoietin.

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mentioning

confidence: 99%

Erythropoietin production in kidney tubular cells

Maxwell¹,

Lappin²,

Johnston³

et al. 1990

Br J Haematol

114

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Hematopoiesis and the Red Blood Cell

Koury¹,

Bauer²

1996

Comprehensive Human Physiology

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The molecular mechanism of erythropoietin action

Koury¹,

Bondurant²

1993

EJB Reviews

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Fax: + 1 615 343 4589.Abbreviations. BFU-E, burst-forming-unit erythroid; CFU-E, colony-forming-unit erythroid; CHO, Chinese hamster ovary; EPO, erythropoietin; FVA cells, splenic erythroblasts from mice infected with Friend leukemia virus (anemia-inducing strain); GATA-I, transcription factor that binds DNA sequence GATA in erythroid cells; GM-CSF, granulocyte-macrophage colony-stimulating factor; HCD cells, an erythropoietin-dependent murine erythroleukemia cell line; rh-EPO, recombinant human erythropoietin; SFFVp, Friend spleen focus-forming virus (polycythemia-inducing); uh-EPO, urinary human erythropoietin; IL, interleukin.

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The Mechanism of Action of Erythropoietin: Erythroid Cell Response

Cited by 6 publications

References 398 publications

Erythropoietin production in kidney tubular cells

Erythropoietin production in kidney tubular cells

Hematopoiesis and the Red Blood Cell

The molecular mechanism of erythropoietin action

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