The mechanism of action of myricetin against lung adenocarcinoma based on bioinformatics, in silico and in vitro experiments

Hao, Pengfei; Zhang, Chaoyun; Bian, Hua; Li, Yixian

doi:10.1007/s00210-023-02859-x

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Apigenin has antioxidative, anti-inflammatory and anticancer activities by inhibits GLUT-1 mRNA and protein expression in head and neck cancers [188]. Myricetin inhibited the proliferation and induced the apoptosis of H1975 cells by regulating the expression of MMP 1, MMP 3, MMP 9 and PIK3R1 genes and in various pathways [189]. Nnaringin induced osteoblastic differentiation of BMSCs by activating the BMP2/Runx2/Osterix signaling pathway and promoted the regulation of oestrogen receptor pathway protein expression, a more significant in vivo ectopic osteogenic effect [190].…”

Section: Flavonoids Mechanismmentioning

confidence: 99%

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Zeng,

Ahmed,

et al. 2024

Preprint

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Nutrition therapy is the best solution to human chronic diseases, especially beer and barley which play an important role in human health and civilization. We demonstrated the actional mechanism of functional ingredients in beer and barley to combat chronic diseases, based on PubMed, google, CNKI, and ISI Web of Science databases from 1997 to 2024. Beer is rich in functional ingredients that is a complex of barley malt and hops; the health effect of beer against 26 chronic diseases is highly similar to that of barley, due to molecular mechanism of polyphenols (phenolic acids, flavonoids), melatonin, minerals, bitter acids, vitamins, and peptides. The ancient German Beer Purity Law provides much scientific basis today, especially indirectly supporting the human one cell disease theory. Low purine beer can be produced by enzymatic and biological degradation and adsorption of purines as well as dandelion addition. Functional beer with low purine and high active ingredients made from Beer Purity and barley malt as well as functional foods addition will be the key and important development direction, such as ginger beer and ginseng beer, especially coix-lily beer at the ancestors ca. 9000 years ago. This review paper not only reveals the actional mechanism of beer overcoming human chronic diseases, but also provides scientific basis for the development of functional beer for the prevention and treatment of human chronic diseases.

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Section: Flavonoids Mechanismmentioning

confidence: 99%

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Zeng,

Ahmed,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Physiological Mechanisms by Which the Functional Ingredients in Beer Impact Human Health

Zeng,

Ahmed,

et al. 2024

Molecules

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Nutritional therapy, for example through beer, is the best solution to human chronic diseases. In this article, we demonstrate the physiological mechanisms of the functional ingredients in beer with health-promoting effects, based on the PubMed, Google, CNKI, and ISI Web of Science databases, published from 1997 to 2024. Beer, a complex of barley malt and hops, is rich in functional ingredients. The health effects of beer against 26 chronic diseases are highly similar to those of barley due to the physiological mechanisms of polyphenols (phenolic acids, flavonoids), melatonin, minerals, bitter acids, vitamins, and peptides. Functional beer with low purine and high active ingredients made from pure barley malt, as well as an additional functional food, represents an important development direction, specifically, ginger beer, ginseng beer, and coix-lily beer, as consumed by our ancestors ca. 9000 years ago. Low-purine beer can be produced via enzymatic and biological degradation and adsorption of purines, as well as dandelion addition. Therefore, this review paper not only reveals the physiological mechanisms of beer in overcoming chronic human diseases, but also provides a scientific basis for the development of functional beer with health-promoting effects.

show abstract

The mechanism of action of myricetin against lung adenocarcinoma based on bioinformatics, in silico and in vitro experiments

Cited by 2 publications

References 54 publications

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Physiological Mechanisms by Which the Functional Ingredients in Beer Impact Human Health

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