The mechanism of action of Bay g 2821: a new diuretic

Mussche, M. M.; Lameire, Norbert

doi:10.1185/03007997709109334

Cited by 7 publications

(1 citation statement)

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“…To investigate the site of action of muzolimine in man, acute water diuresis and hydropenic studies were carried out after single oral doses (6,66). The results confirm that the main site of action is the medullary part of the TALH.…”

Section: Clinical Pharmacologymentioning

confidence: 73%

Muzolimine

Garthoff

Hanisch

1984

Cardiovascular Drug Reviews

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Section: Clinical Pharmacologymentioning

confidence: 73%

Muzolimine

Garthoff

Hanisch

1984

Cardiovascular Drug Reviews

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Diuretic and Uricosuric Agents

Fink

McKenna

Werner

2003

Burger's Medicinal Chemistry and Drug Discovery

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Herein is presented the development and therapeutic use of diuretic agents, a topic that constitutes one of the most significant advances in medicine made during the twentieth century. Diuretics are among the most frequently prescribed therapeutic agents for the treatment of edema, hypertension, and congestive heart failure and they act primarily by inhibiting the reabsorption of sodium ions from the renal tubules in the kidney. Recent advances in renal and ion‐transport research have led to a more precise understanding of the cellular mechanisms of actions of the various classes of diuretic agents. This understanding has aided the design of newer and more effective agents. Today diuretics are grouped as loop, potassium‐sparing, thiazide, or osmotic diuretics and include compounds that have combined diuretic and uricosuric properties. Uricosuric agents increase the excretion of uric acid, a principal product of purine metabolism; and because hyperuricemia is an adverse effect sometimes observed with diuretic treatment, arising from decreased extracellular volume and increased urate reabsorption, this combined property is advantageous. However, given that diuretics themselv are convenient, inexpensive, and generally are well tolerated, they will probably continue to play a role in the treatment of hypertension.

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Effects of Diuretics on Renal Function

Puschett

Winaver

1992

Comprehensive Physiology

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The sections in this article are: Diuretic Effects on Renal Hemodynamics Drugs That Primarily Alter Glomerular Function Drugs That Primarily Alter Tubular Function Diuretic Effects on Intrarenal Blood Flow Distribution Diuretic Interactions with the Renin–Angiotensin‐Aldosterone system Diuretic Interactions with Prostaglandin Synthesis and with the Inhibition of Prostaglandin Synthetase Nephron Sites of Action and Effects of Diuretics on Solute Excretion Review and Comparison of Methodologies Utility of the Clearance Technique for the Study of Diuretic Site and Mechanism of Action in Man Diuretic Effects on the Excretion of Specific Solutes Cellular and Molecular Actions of Diuretics Carbonic Anhydrase Inhibitors Loop Diuretics Thiazides Mineralcorticoid Antagonists Amiloride

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The mechanism of action of Bay g 2821: a new diuretic

Cited by 7 publications

References 0 publications

Muzolimine

Muzolimine

Diuretic and Uricosuric Agents

Effects of Diuretics on Renal Function

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