The mechanism-based toxicity screening of particles with use in the food and nutrition sector via the ToxTracker reporter system

Brown, David M.; Danielsen, Pernille Høgh; Derr, Remco S.; Moelijker, Nynke; Fowler, Paul; Stone, Vicki; Hendriks, Giel; Möller, Peter; Kermanizadeh, Ali

doi:10.1016/j.tiv.2019.104594

Cited by 17 publications

(16 citation statements)

References 36 publications

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“…The literature search resulted in 59 papers for “genotoxicity & 3D in vitro model”, 73 papers for “genotoxicity & advanced in vitro model”, 134 papers for “genotoxicity & high throughput”, eight papers for “genotoxicity & high throughput & nanomaterials” [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ] and six papers for “genotoxicity & high throughput & nanoparticles” (4 are the same as for “genotoxicity & high throughput & nanomaterials”) [ 16 , 17 , 18 , 19 , 21 , 22 ], seven papers for “genotoxicity & organ on chip“ [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ], seven papers for “genotoxicity & 3D models & nanoparticles” [ 30 , 31 , 32 , 33 , 34 , 35 , 36 ], 11 papers for “genotoxicity & 3D models & nanomaterials” [ 30 , 31 , 33 , 36 , 37 , 38 , 39 , 40 , 41 ] for the period of 20 years (2000–2020), whereby the year 2020 was considered only from January to August. ( Table 1 ).…”

Section: Results Of Literature Searchmentioning

confidence: 99%

“…The literature search resulted in 59 papers for "genotoxicity & 3D in vitro model", 73 [16][17][18][19]21,22], seven papers for "genotoxicity & organ on chip" [23][24][25][26][27][28][29], seven papers for "genotoxicity & 3D models & nanoparticles" [30][31][32][33][34][35][36], 11 papers for "genotoxicity & 3D models & nanomaterials" [30,31,33,[36][37][38][39][40][41] for the period of 20 years (2000-2020), whereby the year 2020 was considered only from January to August. (Table 1).…”

Section: Results Of Literature Searchmentioning

confidence: 99%

“…The ToxTracker assay (mechanism-based reporter assay based on embryonic stem cells that uses GFP-tagged biomarkers for detecting DNA damage, oxidative stress and general cellular stress) is a tool that could prove useful in the field of NM toxicology allowing for high throughput screening [ 18 , 194 ].…”

Section: High Throughput Methodsmentioning

confidence: 99%

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Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review

et al. 2020

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Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal or (during mitosis) whole genome level. The study of mechanisms leading to genotoxicity is crucially important, as well as the detection of potentially genotoxic compounds. We consider the current state of the art and describe here the main endpoints applied in standard human in vitro models as well as new advanced 3D models that are closer to the in vivo situation. We performed a literature review of in vitro studies published from 2000–2020 (August) dedicated to the genotoxicity of nanomaterials (NMs) in new models. Methods suitable for detection of genotoxicity of NMs will be presented with a focus on advances in miniaturization, organ-on-a-chip and high throughput methods.

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Section: Results Of Literature Searchmentioning

confidence: 99%

Section: Results Of Literature Searchmentioning

confidence: 99%

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Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review

et al. 2020

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“…Clay E appeared to be the most bioreactive of the “clay” samples. However, it only contains 5% “clay minerals” and significantly contains 91% quartz, a mineral that has applications as the bioreactive positive control in many different types of toxicological assays [ 54 , 55 ]. Although good crystalline structure could be seen, the mineralogy and microscopy suggested that the clay could be more accurately described as a very finely ground quartz powder.…”

Section: Discussionmentioning

confidence: 99%

A New Look at the Purported Health Benefits of Commercial and Natural Clays

et al. 2021

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Clays attributed to have medicinal properties have been used since prehistoric times and are still used today as complementary medicines, which has given rise to unregulated “bioceutical” clays to treat skin conditions. Recently, clays with antibacterial characteristics have been proposed as alternatives to antibiotics, potentially overcoming modern day antibiotic resistance. Clays with suggested antibacterial properties were examined to establish their effects on common wound-infecting bacteria. Geochemical, microscopical, and toxicological characterization of clay particulates, their suspensions and filtered leachates was performed on THP-1 and HaCaT cell lines. Cytoskeletal toxicity, cell proliferation/viability (MTT assays), and migration (scratch wounds) were further evaluated. Clays were assayed for antibacterial efficacy using minimum inhibitory concentration assays. All clays possessed a mineral content with antibacterial potential; however, clay leachates contained insufficient ions to have any antibacterial effects. All clay leachates displayed toxicity towards THP-1 monocytes, while clay suspensions showed less toxicity, suggesting immunogenicity. Reduced clay cytotoxicity on HaCaTs was shown, as many leachates stimulated wound-healing responses. The “Green” clay exhibited antibacterial effects and only in suspension, which was lost upon neutralization. pH and its interaction with clay particle surface charge is more significant than previously understood to emphasize dangers of unregulated marketing and unsubstantiated bioceutical claims.

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“…The largest production of nanoparticles today, however, is not for biomedical or sensory applications, but to enhance material properties, for agricultural applications [12,26,27], in the food industry [9, 12, 15-19, 22, 26, 27] and in cosmetics [20][21][22]. For example, silver, ZnO and CuO nanoparticles are increasingly used as biocides [8,9,13,16,[18][19][20][28][29][30]. There is however increasing evidence of their threat to "non-target" organisms [8,9,13,16,[18][19][20]28].…”

Section: A Thorough Assessment Of Potential Health Risks Is Urgently mentioning

confidence: 99%

Nanosensors and particles: a technology frontier with pitfalls

Vogel

2019

J Nanobiotechnol

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As we are approaching 20 years after the US National Nanotechnology Initiative has been announced, whereby most of that funding was spend to engineer, characterize and bring nanoparticles and nanosensors to the market, it is timely to assess the progress made. Beyond revolutionizing nonmedical applications, including construction materials and the food industry, as well as in vitro medical diagnostics, the progress in bringing them into the clinic has been far slower than expected. Even though most of the advances in nanosensor and nanoparticle research and development have been paid for by disease-oriented funding agencies, much of the gained knowledge can now be applied to treat or learn more about our environment, including water, soil, microbes and plants. As the amount of engineered nanoparticles that enter our environment is currently exponentially increasing, much tighter attention needs to be paid to assessing their health risk. This is urgent as the asbestos story told us important lessons how financial interests arising from a rapid build up of a flourishing industry has blocked and is still preventing a worldwide ban on asbestos, nearly 100 years after the first health risks were reported.

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The mechanism-based toxicity screening of particles with use in the food and nutrition sector via the ToxTracker reporter system

Cited by 17 publications

References 36 publications

Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review

Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review

A New Look at the Purported Health Benefits of Commercial and Natural Clays

Nanosensors and particles: a technology frontier with pitfalls

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