The Mechanism And Structure Of The Gastric H,K-ATPase

Rabon, E.

doi:10.1146/annurev.physiol.52.1.321

Cited by 21 publications

(24 citation statements)

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“…For details see text (section 4). Gleeson Functional roles of acid base transport systems (1) REGULATION OF INTRACELLULAR pH (pHi) In most cells, pHi is actively maintained between 7.00 and 7.40, almost one unit above the value expected if intracellular and extracellular H+ were in electrochemical equilibrium. Furthermore, pHi can recover spontaneously to baseline within minutes after exposure of cells to acute acid and alkaline loads.…”

Section: Gleesonmentioning

confidence: 99%

Acid-base transport systems in gastrointestinal epithelia.

Gleeson¹

1992

Gut

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Section: Gleesonmentioning

confidence: 99%

Acid-base transport systems in gastrointestinal epithelia.

Gleeson¹

1992

Gut

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“…Unlike other K+/H+ antiporters, here protons and potassium ions are moved against their chemical gradients, a process requiring energy (Sachs et al, 1982). This gastric K+/H+-ATPase can be competitively inhibited and the acid secretion stopped by tertiary amines such as TFP and VRP (Rabon and Reuben, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…The K+induced H+ extrusion system described here is energy dependent and pumps H+ out of the cell while bringing K+ in. The functional similarity of these two mechanisms on the H+ efflux suggests that the proton pumping ATPase may be a K+-mediated ATPase as is the K+IH+-ATPase in vertebrate gastric parietal cells (Rabon and Reuben, 1990). With this in mind, several ATPase-specific inhibitors were employed in the present study to assess the possibility that it is in fact a K'/H+-ATPase.…”

Section: Effects Of Atpase Inhibitors On K+-induced H+ Effluxmentioning

confidence: 99%

Plasma membrane K⁺/H⁺‐ATPase From leishmania donovani

Jiang

Anderson

Winget

et al. 1994

Journal Cellular Physiology

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Leishmania donovani has an active K+/H+ exchange system on the surface membrane. Modulation of external K+ concentration resulted in a corresponding change in internal pH (pHi) suggesting a link between proton and potassium transport. Although a Na+/H+ antiporter is present on the plasma membrane, its sensitivity to amiloride suggests that it operates independent of K+/H+ exchange. Reduction of cellular ATP with NaN3 and KCN inhibits K+/H+ exchange showing thereby that the process is energy dependent. The K+/H+ exchange is sensitive to inhibitors of the gastric K+/H(+)-ATPase. It is concluded that the H(+)-ATPase previously reported on the plasma membrane of L. donovani is in fact a K+/H(+)-ATPase.

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“…Omeprazole is the first of a new class of drugs that inhibit gastric secretion by altering the activity of hydrogen/ potassium ATPase. 24 25 This drug has been used in a variety of patients for whom hyperacidity is a major problem (for example, Zollinger-Ellison syndrome) and who have been refractory to more conventional H2 blockers or antacids. 26 Studies have implicated the long term use of omeprazole in gastric carcinoma in rats, secondary hypergastrinaemia, and hyperplasia of enterochromaffin cells.…”

Section: Discussionmentioning

confidence: 99%