The Mechanism and Function of <scp>miRNA</scp> in Intervertebral Disc Degeneration

Wang, Chenglong; Cui, Liqiang; Gu, Qinwen; Guo, Sheng; Zhu, Bin; Liu, Xueli; Li, Yujie; Wang, Dingxuan; Li, Sen

doi:10.1111/os.13204

Cited by 23 publications

(17 citation statements)

References 60 publications

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“…Biological processes showed that IDD was closely bound up with regulation of inflammatory response, positive regulation of cytokine production, endogenous cell promotion and other items. A number of current studies have shown that various genes can regulate the proliferation and apoptosis of intervertebral disc cells, or promote and inhibit the release of inflammatory factors to regulate the development of IDD [4]. The cell composition involved cell substrate junction.…”

Section: Discussionmentioning

confidence: 99%

“…MiRNAs can bind to target mRNAs to destabilize them and inhibit mRNAs translation or cause their degradation, thus achieving post-transcriptional regulation of gene expression. MiRNAs play an important role in the biological process of IDD and participate in it by regulating inflammatory response, cell proliferation, cell apoptosis and other pathways [4,5]. Dong found that miR-640 inhibited the expression of β-catenin and EP300, thereby suppressing WNT signalling and inducing nucleus pulposus cell degeneration [6].…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive analysis of potential ceRNA network and immune cell infiltration in intervertebral disc degeneration

et al. 2022

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Background Intervertebral disc degeneration (IDD) has become a serious public health problem, the mechanism of which is complex and still unclear. We aimed to construct a ceRNA network related to IDD to explore its pathogenesis. Methods We downloaded the GSE67566, GSE63492, GSE116726 and GSE124272 datasets from GEO database, and obtained the differentially expressed RNAs. Then, we constructed a ceRNA network and the KEGG and GO enrichment analysis were performed. Finally, we performed immune cell infiltration analysis on the GSE124272 dataset and analysed the correlation between immune cell abundance and hub genes expression levels. Results The ceRNA network included three down-regulated circRNAs: hsa_circ_0074817, hsa_circ_0002702, hsa_circ_0003600, three up-regulated miRNAs: hsa-miR-4741, hsa-miR-3158-5p, hsa-miR-508-5p, and 57 down-regulated mRNAs, including six hub genes: IGF1, CHEK1, CCNB1, OIP5, BIRC5, AR. GO and KEGG analysis revealed that the network is involved in various biological functions. Immune infiltration analysis showed that IDD was closely related to immune cell infiltration, and hub genes could further affect the development of IDD by affecting immune cell infiltration. Conclusion This study identified the hsa_circ_0074817-hsa-miR-508-5p-IGF1/CHEK1/CCNB1, the hsa_circ_0003600-hsa-miR-4741-BIRC5/OIP5/AR and the hsa_circ_0002702-hsa-miR-3158-5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of potential ceRNA network and immune cell infiltration in intervertebral disc degeneration

et al. 2022

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“…The interaction and abnormal expression of inflammatory factors can disrupt the balance of ECM metabolism, cause inflammation, and accelerate IVDD. Tumor necrosis factor (TNFα), interleukins (IL), nitric oxide, and prostaglandin E2 (PGE 2 ) are the main factors for the inflammatory reaction in IVD [ 29 ]. Cytokines initiate the inflammatory cascade by stimulating a range of pathogenic responses in the disc cells that could promote autophagy, senescence, and apoptosis.…”

Section: Intervertebral Disc Degenerationmentioning

confidence: 99%

“…There exists no effective, surgical or non-surgical treatment for IVDD nowadays, which is largely related to the lack of knowledge of the specific mechanisms of IVDD, and the lack of effective specific therapeutic targets [ 29 ].…”

Section: Treatments For Ivddmentioning

confidence: 99%

The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment

Grangeat

Erario

2023

IJMS

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Degeneration of the intervertebral disc is one of the most frequent causes of lumbar pain, and it puts an extreme strain on worldwide healthcare systems. Finding a solution for this disease is an important challenge as current surgical and conservative treatments fail to bring a short-term or long-term solution to the problem. Medical ozone has yielded excellent results in intervertebral disc pathology. When it comes to extruded disc herniation, ozone is the only etiological treatment because it stimulates the immune system to absorb the herniated portion of the nucleus pulposus, thus resolving discal extrusion. This work aims to examine the biomolecular mechanisms that lead to intervertebral disc degeneration while highlighting the significance of oxidative stress and chronic inflammation. Considering that ozone is a regulator of oxidative stress and, therefore, of inflammation, we assert that medical ozone could modulate this process and obtain inflammatory stage macrophages (M1) to switch to the repair phase (M2). Consequently, the ozone would be a therapeutic resource that would work on the etiology of the disease as an epigenetic regulator that would help repair the intervertebral space.

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“…MiRNAs play an important role in the occurrence and development of tendon injuries, osteoarthritis, rheumatoid arthritis, IDD, and other diseases [ 11 – 13 ]. Although some studies have reported the role of miRNAs in IDD [ 14 , 15 ], scientific econometric analysis in this field has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Research hotspots and trends of microRNAs in intervertebral disc degeneration: a comprehensive bibliometric analysis

Chen

Wang

et al. 2023

J Orthop Surg Res

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Background MicroRNAs (miRNAs) are involved in various pathological processes, such as proliferation, growth, and apoptosis, of intervertebral disc (IVD) cells and play an important role in the development of intervertebral disc degeneration (IDD). Although some studies have reported the role of miRNAs in IDD, scientific econometric analysis in this field is not available. Objectives We designed this study to describe the current research trends and potential mechanisms associated with the role of miRNAs in IDD and to provide new ideas for future research in this field. Methods We conducted a bibliometric analysis of the publications on the role of miRNAs in IDD included in the Web of Science core collection database to elucidate the current research trends in this field. The potential mechanisms were constructed using the Arrowsmith project. Results We found that the number of miRNAs and IDD-related publications increased over the years. China was the most important contributor to research in this field. The top three institutions in terms of number of articles published were Huazhong University of Science and Technology, Shanghai Jiao Tong University, and Xi’an Jiao Tong University. Shanghai Jiao Tong University had the highest number of citations. Experimental and thermal medicine had the maximum number of documents, and Cell promotion had the most citations. The journal with the most mean times cited per study was Annals of the Rheumatic Diseases. The author Wang K had the highest number of publications, and Wang HQ had the highest number of citations. These two authors made important contributions to the research in this field. The keyword analysis showed that recent studies have focused on miRNAs regulating nucleus pulposus cell apoptosis and proliferation. Moreover, we revealed the potential mechanisms of miRNAs associated with IDD, including miRNAs regulating the extracellular matrix (ECM) degradation, mediating cartilage endplate (CEP) degeneration, and participating in inflammatory responses. Conclusion We demonstrated the knowledge map of miRNAs and IDD-related research through bibliometric analysis and elucidated the current research status and hotspots in this field. The mechanisms by which miRNAs regulate the apoptosis and proliferation of degenerated IVDs, promote ECM degradation, mediate CEP degeneration, and participate in inflammatory responses should be explored in further studies.

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The Mechanism and Function of miRNA in Intervertebral Disc Degeneration

Cited by 23 publications

References 60 publications

Comprehensive analysis of potential ceRNA network and immune cell infiltration in intervertebral disc degeneration

Comprehensive analysis of potential ceRNA network and immune cell infiltration in intervertebral disc degeneration

The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment

Research hotspots and trends of microRNAs in intervertebral disc degeneration: a comprehensive bibliometric analysis

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