The mechanics involved in ADPKD and nephrolithiasis interaction

Abstract

The incidence of autosomal dominant polycystic kidney disease (ADPKD) is about 1 in 1,000, and its mortality rate is high. So far, beyond dialysis and kidney transplants, there is no better way to slow or completely cure the disease. However, both of which bring huge economic burdens to patients and society. Autosomal dominant polycystic kidney disease is characterized by numerous fluid-filled cysts on the surface of the kidneys. This can lead to tubular dilation and kidney failure. Proteinuria, kidney stones, hematuria, and cyst bleeding are common symptoms of ADPKD. Recent studies have found that the occurrence of adpkd is associated with pkd1 and pkd2 gene mutations, in which clinical data show that mutations in Pkd1 cause 60%-78% of Adpkd, while mutations in Pkd2 cause 15%-26%. Some environmental factors, such as kidney stones, can lead to adpkd, but the exact mechanism remains unclear. In this article, which introduce about autosomal dominant from the historical background of PKD, recent research results, the genetic mechanism of ADPKD, the impact of stones on ADPKD, and the basic damage of ADPKD to the kidney. Information about polycystic kidney disease.