The measurement of endometrial volume and sub-endometrial vascularity to replace the traditional endometrial thickness as predictors of <i>in-vitro</i> fertilization success

Maged, Ahmed M.; Kamel, Ahmed; Abuhamila, Fouad A.; Elkomy, Rasha; Ohida, Omar A; Hassan, S. M.; Ramadan, Wafaa

doi:10.1080/09513590.2019.1604660

Cited by 18 publications

(20 citation statements)

References 20 publications

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“…Therefore, we considered 3ml as the cut-off value of endometrial volume and divided it into two groups with scores of 0 and 1 respectively. Ahmed et al reported that endometrial volume can be a candidate predictor of in-vitro fertilization success to replace the traditional endometrial thickness, because it was significantly differenced between pregnant and non-pregnant women on day of triggering and embryo transfer ( 26 ). On the contrary, Assen et al analyzed 142 patients in their study and found that endometrial volume assessed by 3D transvaginal ultrasound was not a useful tool for predicting pregnancy in single blastocyst embryo transfer cycles and the AUC was 0.48 ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

An endometrial receptivity scoring system basing on the endometrial thickness, volume, echo, peristalsis, and blood flow evaluated by ultrasonography

et al. 2022

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BackgroundEstablishing a successful pregnancy depends on the endometrium and the embryo. It is estimated that suboptimal endometrial receptivity account for one-third of implantation failures. Despite the indepth understanding of the processes associated with embryo-endometrial cross-talk, little progress has been achieved for diagnosis and treatments for suboptimal endometrial receptivity.MethodsThis retrospective study included women undergoing their first frozen-thawed embryo transfer (FET) cycles at our reproductive medicine center from March 2021 to August 2021. Transvaginal three-dimensional (3D) ultrasound was performed in the morning on the day of embryo transfer for all the thawed embryo transfer patients, to evaluate endometrial receptivity, including endometrial thickness, echogenicity, volume, movement and blood flow.ResultsA total number of 562 patients of FET with 315 pregnancies (56.0%) was analyzed. It was found that only the echo of the endometrial central line was different between the pregnant group and non-pregnant group. Other parameters, such as endometrial thickness, volume, endometrial peristalsis, or the endometrial blood flow were not statistically different between the two groups. Then, according to the relationship between the different groups and the clinical pregnancy rate, a score of 0 to 2 was respectively scored. The sum of the scores for the six items was the patient’s endometrial receptivity score. It showed that the clinical pregnancy rate increased as the endometrial receptivity score increased, and when the receptivity score reaches at least 5, the clinical pregnancy rate is significantly improved (63.7% versus 49.5%, P=0.001).ConclusionWe developed an endometrial receptivity scoring system and demonstrated its validity. It may aid clinicians in choosing the useful marker in clinical practice and for informing further research.

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Section: Discussionmentioning

confidence: 99%

An endometrial receptivity scoring system basing on the endometrial thickness, volume, echo, peristalsis, and blood flow evaluated by ultrasonography

et al. 2022

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“…EMT has been broadly acknowledged as a prognostic indicator for endometrial receptivity, but the results are controversial (2,(9)(10)(11)(12)(13). In most previous studies, EMT was monitored during ovarian stimulation in fresh embryo transfer cycles, or during the endometrium proliferation phase in frozenthawed embryo transfer (FET) cycles, or in the luteal phase on the embryo transfer day (2,(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Effect of Endometrial Thickness Change in Response to Progesterone Administration on Pregnancy Outcomes in Frozen-Thawed Embryo Transfer: Analysis of 4465 Cycles

Zhang

Gao

et al. 2020

Front. Endocrinol.

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“…Maged et al [ 13 ] used two-dimensional transvaginal ultrasound and a 3D power Doppler ultrasound to measure endometrial volume and sub-endometrial blood perfusion in 82 patients undergoing embryo transfer on the hCG day and ET day, respectively. The results showed a statistically significant difference in the endometrial volume between pregnant and nonpregnant groups ( P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

A predictive model for first-trimester pregnancy inception after IVF-ET based on multimodal ultrasound evaluation of endometrial receptivity

et al. 2022

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Background In-vitro fertilization-embryo transfer (IVF-ET) is a commonly used assisted reproductive technology. Its success depends on many factors, including endometrial receptivity. Endometrial receptivity can be evaluated by ultrasound, endometrial biopsy, and magnetic resonance imaging. Compared with the latter two methods, ultrasound has the advantages of wide availability, non-invasiveness, and low cost. Three-dimensional (3D) ultrasound imaging examines endometrial thickness, morphology, and blood vessels, which are associated with the success of embryo implantation. However, there are no reports of endometrial receptivity assessment by 3D ultrasound. Therefore, we aimed to evaluate endometrial receptivity using 3D ultrasound and construct a predictive model for first-trimester pregnancy inception following IVF-ET. Methods We performed a prospective observational study on infertile women who underwent IVF-ET between December 2019 and February 2021. These women had 3D ultrasound evaluations, measuring endometrial thickness, volume, pattern, morphology, peristalsis, uterine artery blood flow index, sub-endometrial blood flow index, and distribution pattern. We recorded the occurrence of first-trimester pregnancies in these women. Using Akaike information criterion (AIC) and backward stepwise regression, a first-trimester pregnancy prediction model was constructed based on the minimum AIC value and validated internally and externally. Results 111 women were enrolled, with 103 included in the analysis. Univariate and multiple logistic regression analyses showed that endometrial thickness and vascularization flow index (VFI) were independent factors associated with the occurrence of a pregnancy. The final prediction model corresponding to the minimum AIC value (65.166) was Y = − 6.131–0.182endometrial thickness + 0.542endometrial volume + 4.374VFI + 0.132age. In the test set, modeling cohort, and external validation cohort, the model showed satisfactory differentiation, with C index of 0.841 (95%CI 0.699–0.817), 0.727 (95%CI 0.619–0.815), and 0.745 (95%CI 0.671–0.840), respectively. The Hosmer–Lemeshow goodness of fit tests reported P = 0.865, 0.139, and 0.070, respectively, indicating a high agreement with the actual IVF-ET outcome. This model reached the highest diagnostic efficiency (sensitivity 88.9%, specificity 75%, Youden index 0.639) at a diagnostic cut-off value of ≥ 0.360. Conclusions The predictive model based on endometrial receptivity evaluations by 3D ultrasound had high diagnostic efficiency and could be a simple and effective tool to predict first-trimester pregnancy inception after IVF-ET.

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The measurement of endometrial volume and sub-endometrial vascularity to replace the traditional endometrial thickness as predictors of in-vitro fertilization success

Cited by 18 publications

References 20 publications

An endometrial receptivity scoring system basing on the endometrial thickness, volume, echo, peristalsis, and blood flow evaluated by ultrasonography

An endometrial receptivity scoring system basing on the endometrial thickness, volume, echo, peristalsis, and blood flow evaluated by ultrasonography

Effect of Endometrial Thickness Change in Response to Progesterone Administration on Pregnancy Outcomes in Frozen-Thawed Embryo Transfer: Analysis of 4465 Cycles

A predictive model for first-trimester pregnancy inception after IVF-ET based on multimodal ultrasound evaluation of endometrial receptivity

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