The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives

İnanç, Tuğrul; Kaya, Mehmet; Yarlıoğlueş, Mikail; Ardıç, İdris; Özdoğru, İbrahіm; Doğan, Ali; Kalay, Nihat; Güntürk, Ertuğrul Emre; Günebakmaz, Özgür; Gül, İbrahim; Topsakal, Ramazan

doi:10.3109/08037050903516284

Cited by 49 publications

(40 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contrary to most previous studies, (3)(4)(5)(6)(7)(8) factors in atherogenesis and also in CV risk prediction. Namely, the FRS does not account for metabolic syndrome which is strongly associated with atherogenesis, and often underestimates total CV risk in patients with these risk factors.…”

Section: Discussioncontrasting

confidence: 70%

Correlation between mean platelet volume and total risk of cardiovascular disease

Marković

Carević

Bonacin

et al. 2013

View full text Add to dashboard Cite

Introduction. The association between mean platelet volume (MPV) and single cardiovascular disease (CVD) risk factors has previously been tested. The aim of our study was to evaluate the association between MPV and total risk of CVD. Materials and Methods. In 216 consecutive outpatients referred for a cardiology assessment because of multiple CVD risk factors, total CVD risk was estimated according to the Framingham Risk Score (FRS) as low (<10%), intermediate (11-19%), and high (>20%). Additionally, FRS was adjusted for triglycerides (TG), body mass index (BMI) and a family history of CVD, important CVD risk factors which are not included in the FRS equation. Also, CVD risk was estimated according to terciles of MPV (<8.3, >9.1 fL, respectively). Correlation between high sensitivity C-reactive protein (hs-CRP) and FRS was used as confirmation that our study hypothesis was properly set. (OR 2.2; P =0.038). In comparison, P=0.004) and adjusted (r=0.383, P<0.001 Results. MPV did not correlate with individual CVD risk factors or with FRS, either before, or after adjustment for additional CVD risk factors. Significant correlation between MPV and total CV risk was observed only in the adjusted high FRS group; namely, for persons in tercile 3, CVD risk was doubled

show abstract

Section: Discussioncontrasting

confidence: 70%

Correlation between mean platelet volume and total risk of cardiovascular disease

Marković

Carević

Bonacin

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Nocturnal decline in BP is a physiological condition [18]. Subjects in whom this nocturnal reduction in BP is blunted are named non-dippers whereas the others are classified as dippers [4,5,6,7,8].…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

et al. 2012

Self Cite

View full text Add to dashboard Cite

Objectives: Because both high red cell distribution width (RDW) and non-dipping hypertension are closely related to adverse cardiovascular outcomes and higher inflammatory status, we aimed to investigate whether there is any relationship between RDW and dipping/non-dipping hypertension status. Methods: The present study involved 123 hypertensive patients and 65 age- and gender-matched healthy, normotensive subjects. Hypertensive patients were divided into two groups: 56 dipper patients (20 males, mean age 51.9 ± 15.3 years) and 67 non-dipper patients (27 males, mean age 55.6 ± 15.0 years). If the systolic daytime blood pressure (BP) of the patients decreased by at least 10% during the nighttime, these subjects were ‘dippers’, and all other subjects were ‘non-dippers’. Results: Both dipper patients and non-dipper patients had higher levels of RDW compared to normotensives (13.5 ± 0.89 and 14.1 ± 1.33 vs. 13.0 ± 1.42%, p = 0.027 and p <0.001, respectively). Also RDW values in non-dippers were statistically higher compared to those in dippers (p = 0.008). Although there were negative correlations between RDW values and nocturnal systolic BP fall (p = 0.027, r = –0.199) and diastolic BP fall (p = 0.383, r = –0.079) in all hypertensive patients, these correlations did not reach a statistically significant level. Conclusion: Our study demonstrates that non-dippers have high RDW levels compared to both dippers and controls.

show abstract

“…In fact, previous studies have found elevated MPV values in resistant hypertension 6 and non-dipper hypertension. 7 However, whether an elevated MPV can independently predict future risk for hypertension has not been noted in the literature. In the present study, we evaluated whether elevated MPV could independently predict future risk for hypertension.…”

Section: Introductionmentioning

confidence: 99%

Association between mean platelet volume and hypertension incidence

Li¹,

Zhang²,

Zhu³

et al. 2017

Hypertens Res

View full text Add to dashboard Cite

Mean platelet volume (MPV) is increased in various cardiovascular diseases. We sought to determine the prognostic value of MPV for hypertension. We performed a retrospective cohort study. Baseline characteristics were measured in 9168 individuals without hypertension, and the follow-up period was 9 years. Hypertension was confirmed in 2881 participants during the followup period. When the participants were grouped according to MPV quartiles, the hazard ratio of future hypertension gradually increased across the MPV quartiles. The hazard ratios of hypertension for the II, III and IV (high) vs. I (low) quartiles of MPV were 1.13 (95% confidence interval (CI) 1.01-1.25, P = 0.027), 1.25 (95% CI 1.12-1.39, Po0.001) and 1.40 (95% CI 1.26-1.55, Po0.001), respectively. In multivariate Cox regression analysis, MPV predicted hypertension independently of age, sex, platelet count, waist circumference, drinking, systolic blood pressure and creatinine levels. The present study indicated that elevated MPV is associated with increased incidence of hypertension independent of other risk factors, which suggests that platelet activity may play a role in hypertension incidence.

show abstract

The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives

Cited by 49 publications

References 26 publications

Correlation between mean platelet volume and total risk of cardiovascular disease

Correlation between mean platelet volume and total risk of cardiovascular disease

Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

Association between mean platelet volume and hypertension incidence

Contact Info

Product

Resources

About