The MCP‐1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population

Abstract

Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction.

Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg

“…MCP-1 serum levels An association of SNP -2578AO G with MCP-1 serum levels was investigated by several studies (18,(20)(21)(22)(23). Although functionality of this SNP has been previously demonstrated, the results of the association studies remain contradictory (24).…”

“…Type 2 diabetes Several epidemiologic studies have been conducted to discover whether MCP-1 levels are associated with T2DM, although findings were inconsistent (17,18,(20)(21)(22). It was recently suggested that this inconsistency results from the confounding effect of cardiovascular and cerebrovascular conditions.…”

“…The association of the single nucleotide polymorphism (SNP) K2578AOG with higher MCP-1 levels has been investigated in several association studies, although the findings remain controversial (18,(20)(21)(22)(23). Rovin et al demonstrated the functionality of this SNP by showing upregulation of IL-1b-induced MCP-1 gene expression (24).…”

Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population

“…Nucleotide sequences of primers are shown in Table 2. Reaction conditions and internal controls were adopted from the Phototyping meth odology 12 , and the protocol is described elsewhere 13 .…”

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

“…More scientific groups studied CRP gene polymorphisms and found that basal levels of CRP both in patients and healthy controls are genetically determined and under repeated examination in healthy subjects relatively stable. Thus understanding the genetic background of CRP that regulate basal but also by infection or any type of inflammation induced concentration of CRP might contribute to stratification of healthy subjects to different groups with higher or lower degree of cardiovascular disease development (Cermakova et al, 2005;Pearson at al. 2003;Szalai et al, 2002) …”