The Mayo Dysphagia Questionnaire-30: Documentation of Reliability and Validity of a Tool for Interventional Trials in Adults with Esophageal Disease

Abstract

The aim of this study was to develop the Mayo Dysphagia Questionnaire-30 Day (MDQ-30), a tool to measure esophageal dysphagia, by adapting items from validated instruments for use in clinical trials, and assess its feasibility, reproducibility, and concurrent validity. Outpatients referred to endoscopy for dysphagia or seen in a specialty clinic were recruited. Feasibility testing was done to identify problematic items. Reproducibility was measured by test-retest format. Concurrent validity reflects agreement between information gathered in a structured interview versus the patients' written responses. The MDQ-30, a 28-item instrument, took 10 min (range = 5-30 min) to complete. Four hundred thirty-one outpatients [210 (49%) men; mean age = 61 years] participated. Overall, most concurrent validity kappa values for dysphagia were very good to excellent with a median of 0.78 (min 0.28, max 0.95). The majority of reproducibility kappa values for dysphagia were moderate to excellent with a median kappa value of 0.66 (min 0.07, max 1.0). Overall, concurrent validity and reproducibility kappa values for gastroesophageal reflux disease (GERD) symptoms were 0.81 (95% CI = 0.72, 0.91) and 0.66 (95% CI = 0.55, 0.77), respectively. Individual item percent agreement was generally very good to excellent. Internal consistency was excellent. We conclude that the MDQ-30 is an easy-to-complete tool to evaluate reliably dysphagia symptoms over the last 30 days.

PedsQL Eosinophilic Esophagitis Module

“…The test-retest reliability data presented in present study demonstrated that the PedsQL™ EoE Module scales and summary scores did not change to a significant degree over an average interval of ~12 days between instrument administrations in pediatric patients with stable disease. In the adult dysphagia literature, the Mayo Dysphagia Questionnaire (MDQ) was found to be not responsive in a 14 day recall period, but rather performed better over a one month recall period (51). Additionally, there have been a number of responsiveness analyses with the PedsQL™ 4.0 Generic Core Scales in which the one month recall period was demonstrated to be sensitive to intervention effects (27).…”

Elemental Diet Induces Histologic Response in Adult Eosinophilic Esophagitis

“…A partial histologic response was >10 eosinophils / maximal hpf but less than half the immediate pretreatment eosinophil content. Secondary end points were: (1) changes in other histologic fi ndings (mast cell content or parabasal layer thickening), (2) the tempo of changes in these parameters on the elemental diet and aft er reintroducing normal food when the diet ended, and (3) improvement of dysphagia and other specifi c symptoms as scored by the Mayo Dysphagia Questionnaire-30 ( 11 ).…”

Self Dilation as a Treatment for Resistant Benign Esophageal Strictures: Outcome, Technique, and Quality of Life Assessment

“…Patient reported symptom severity and QoL were assessed using selected items from the Mayo Dysphagia Questionnaire-30 Day [8], the Swallowing Difficulty Index, the Swallowing Impact Scale, the MD Anderson Dysphagia Inventory [9], and the SF-12 Ò Questionnaire [10]. Items were selected based on face validity and relevance to patients performing self dilation.…”