The maximum standardized uptake values on positron emission tomography to predict the Noguchi classification and invasiveness in clinical stage IA adenocarcinoma measuring 2 cm or less in size

Abstract

This study investigated whether the standardized uptake value (SUV) of the tumor correlated with the Noguchi classification and tumor invasiveness in patients with clinical stage IA adenocarcinoma < or = 2 cm in size. Fifty-four patients that underwent a curative surgical resection for clinical stage IA adenocarcinoma < or = 2 cm from April 2005 to December 2008 had integrated positron emission tomography (PET)-computed tomography (CT) with 18F-fluorodeoxyglucose (FDG) as part of the preoperative workup. The relationships between the maximum SUV (SUVmax) and Noguchi classification, pathological results of intratumoral lymphatic or vascular invasion of tumor cells, and pleural invasion were examined. In comparison to tumors with an SUVmax>1.0, tumors with an SUVmax < or = 1.0 were more frequently classified as Noguchi type A or B (P<0.0001). Tumors with an SUVmax>1.0 had more intratumoral lymphatic or vascular invasion of tumor cells and pleural invasion (P=0.0005 and P=0.0002). These results suggest that an SUVmax is an important predictor for the Noguchi classification and tumor invasiveness in patients with clinical stage IA adenocarcinoma < or =2 cm in size.

Differentiation of lung neoplasms with lepidic growth and good prognosis from those with poor prognosis using computer-aided 3D volumetric CT analysis and FDG-PET

“…Several studies in which tumor grading of small adenocarcinoma was found to correlate with radiologic findings obtained with TSCT or FDG-PET have been published (8,9). Takashima et al (8) evaluated various thin-section CT findings to differentiate invasive adenocarcinoma with lepidic growth from adenocarcinoma in situ and suggested that percentage of GGO areas of the lesion on transverse TSCT images were most useful for this purpose.…”

“…Takashima et al (8) evaluated various thin-section CT findings to differentiate invasive adenocarcinoma with lepidic growth from adenocarcinoma in situ and suggested that percentage of GGO areas of the lesion on transverse TSCT images were most useful for this purpose. Maeda et al (9) reported that the use of PET SUV max resulted in discrimination between the two categories with 93% accuracy. Takashima et al (8) further found that the prevalence of coarse spiculation in invasive adenocarcinoma with lepidic growth was statistically significantly greater than that in adenocarcinomas in situ.…”

F18-FDG PET-CT analyses of small peripheral adenocarcinoma of the lung

“…Maeda et al (7) analyzed the relationship between PET-CT and tumor subtypes of 54 patients defined by Noguchi et al . (3).…”

“…There are many studies in which high-resolution CT findings were correlated with the histologic subtypes of peripheral adenocarcinoma of the lung defined by Noguchi et al (5, 6). However, there are only a few reports on the relationship of fluorine 18-fluoro-2-deoxyglucose positron emission tomography CT (F18-FDG PET-CT) with this tumor classification (7, 8). In this study, we investigated if visual assessment and maximum standard uptake values (SUV max ) on PET-CT may correlate with the histology grading of small peripheral adenocarcinoma of the lung.…”

Tek Akciğer Nodülü: Güncel Yaklaşım

“…Malignite olasılığı düşük, 8 mm'den kü-çük solid nodül veya subsolid nodül varlığında PET'in duyarlılığı düşer (%47-89) ve yanlış negatif oranı yükselir [3,32,33]. Duyarlılığın dü-şüklüğü, küçük nodüllerin tanınmasında yönte- [33][34][35]. Aslında PET kü-çük, subsolid nodüllerden çok, malign olasılı-ğı yüksek, 10-15 mm'den büyük, kısmi solid TAN'ların değerlendirilmesinde yararlıdır [36].…”