“…The CCP domains of Hig proteins are evolutionarily conserved, play important roles in neuron development, and interact with the surface of several pathogenic viruses (Casasnovas et al, 1999;Xiao et al, 2014Xiao et al, , 2015Nakayama et al, 2016). For example, the CCP domains of Hig homolog of A. aegypti interact with the surface of flaviviruses and effectively restrict flavivirus infection in the CNS of mosquitoes, preventing the lethal flaviviral infection of mosquitoes (Xiao et al, 2014(Xiao et al, , 2015.…”