Abstract:Osseous tissue develops via two distinctly different processes: endochondral (EC) ossification and intramembranous (IM) ossification. The present study tests the hypothesis that each type of osseous tissue contains unique inducing factors for the promotion of cartilage and bone development. Previous work suggests that subcutaneous implants of demineralized EC and IM bone matrices both induce endochondral ossification. Thus, it concludes that the bone growth promotion properties of the respective matrices are v… Show more
“…Scott and her colleagues suggested that osteoinductive proteins from intramembranous bones could induce direct bone formation without catilage, whereas ones from endochondral bones could cause endochondral ossification (Scott and Hightower, 1991;Scott et al, 1994). In contrast, we suggest that BMPs from endochondral bone can induce either direct or endochondral bone formation, depending on the physicochemical property of the carrier.…”
“…Scott and her colleagues suggested that osteoinductive proteins from intramembranous bones could induce direct bone formation without catilage, whereas ones from endochondral bones could cause endochondral ossification (Scott and Hightower, 1991;Scott et al, 1994). In contrast, we suggest that BMPs from endochondral bone can induce either direct or endochondral bone formation, depending on the physicochemical property of the carrier.…”
“…These include the bone's embryologic origin, morphology, cytological constituents, and biochemical composition of the extracellular matrix. 6 Although detailed review of each of these properties is beyond the scope of this report, further discussion of the embryologic origin of donor bone is warranted. The development of any given bone proceeds along one of the two general pathways, either endochondral or intramembranous ossification.…”
Section: Clinical and Scientific Backgroundmentioning
“…There exist compositional differences in bone ECM originating from IM sources during fetal development (e.g., cranium) and EC sources (e.g., femur). 44 Furthermore, DBM originating from IM and EC bone have been shown in a series of studies by Rabie et al 28,[30][31][32] to elicit different healing pathways during regeneration of parietal bone defects in New Zealand White Rabbits. The parietal bone is formed by IM ossification during fetal development, 44 Implanted subcutaneously in nude mice.…”
Section: Coupling In Vivo Developmental Engineering With Native Ecm Bmentioning
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