The matrix effect in secondary ion mass spectrometry

Seah, M. P.; Shard, Alexander G.

doi:10.1016/j.apsusc.2018.01.065

Cited by 30 publications

(21 citation statements)

References 32 publications

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“…Matrix-assisted laser desorption ionization uses a laser energy absorbing matrix to create ions from large molecules with minimal fragmentation . Secondary ion MS generates ions that are then transferred into a mass spectrometer across a high electrostatic potential and are referred to as secondary ions . Desorption spectrometry observes desorbed molecules from a surface when the surface temperature is increased .…”

Section: Technology Of Metabolomicsmentioning

confidence: 99%

Metabolomics for a Millenniums-Old Crop: Tea Plant (Camellia sinensis)

Jiang

Apostolides

et al. 2019

J. Agric. Food Chem.

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Tea cultivation and utilization dates back to antiquity. Today it is the most widely consumed beverage on earth due to its pleasant taste and several beneficial health properties attributed to specific metabolites. Metabolomics has a tremendous potential to correlate tea metabolites with taste and health properties in humans. Our review on the current application of metabolomics in the science of tea suggests that metabolomics is a promising frontier in the evaluation of tea quality, identification of functional genes responsible for key metabolites, investigation of their metabolic regulation, and pathway analysis in the tea plant. Furthermore, the challenges, possible solutions, and the prospects of metabolomics in tea science are reviewed.

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Section: Technology Of Metabolomicsmentioning

confidence: 99%

Metabolomics for a Millenniums-Old Crop: Tea Plant (Camellia sinensis)

Jiang

Apostolides

et al. 2019

J. Agric. Food Chem.

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“…Indeed, the local structure and chemical composition of the matrix material influences the intensity of the emitted secondary ion regardless of the actual element concentration. 22,26 Another limitation of the curvature technique is the differences in inter-diffusion of elements between the enamel and the glass substrates, having different composition. Additionally, the glass transition temperature of the CS77 substrate is 90°C higher than the V95 substrate.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous measurement of coefficient of thermal expansion and biaxial modulus of enamel thick films deposited on glass substrates by curvature technique

Walch

Benedetto

Bacharouche

et al. 2020

Int J of Appl Glass Sci

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The measurement of the thermoelastic properties of enamel thick films deposited onto soda‐lime silicate glass is challenging. The film properties can be modified by the interdiffusion between the glass substrate and the enamel and by the crystallization that occur during the sintering. The average biaxial modulus and coefficient of thermal expansion of several enamel thick films deposited onto 700 µm glass substrates have been simultaneously measured using the curvature method. The value of the coefficient of thermal expansion measured with a dilatometer on enamel bulk samples is significantly higher, associated with the absence of diffusion and a different enamel structure. The interdiffusion of elements between the enamel film and the glass substrate has been demonstrated with Time‐of‐Flight Secondary Ion Mass Spectrometry (TOF‐SIMS). The amount of porosity ratio presents in the enamel film, evaluated via Scanning electron microscopy(SEM), has a great influence on the biaxial modulus. The amount of compressive stress in the enamel, calculated from the film thermoelastic properties, is strongly correlated with the mechanical performance of enameled glasses, investigated by Ring On Ring methods. Therefore, a high Young's modulus for the enamel and a mismatch of the coefficient of thermal expansion between the enamel film and substrate, the film having the lowest value, has been found to increase significantly the mechanical performance of the stack.

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“…This is because the sample matrix influences the ionization probability of analytes, resulting in enhancement or suppression of the signal intensity [77]. These matrix effects are more severe for organic compounds where protonation and charge transfer processes occur [78]. This can be mitigated to some extent by chemical modification of the sample [79] or by coating the sample surface with a layer of matrix prior to MSI experiments.…”

Section: Analysis Of Hair By Mass Spectrometry Imagingmentioning

confidence: 99%

Mapping the Chemistry of Hair Strands by Mass Spectrometry Imaging—A Review

et al. 2021

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Hair can record chemical information reflecting our living conditions, and, therefore, strands of hair have become a potent analytical target within the biological and forensic sciences. While early efforts focused on analyzing complete hair strands in bulk, high spatial resolution mass spectrometry imaging (MSI) has recently come to the forefront of chemical hair-strand analysis. MSI techniques offer a localized analysis, requiring fewer de-contamination procedures per default and making it possible to map the distribution of analytes on and within individual hair strands. Applying the techniques to hair samples has proven particularly useful in investigations quantifying the exposure to, and uptake of, toxins or drugs. Overall, MSI, combined with optimized sample preparation protocols, has improved precision and accuracy for identifying several elemental and molecular species in single strands of hair. Here, we review different sample preparation protocols and use cases with a view to make the methodology more accessible to researchers outside of the field of forensic science. We conclude that—although some challenges remain, including contamination issues and matrix effects—MSI offers unique opportunities for obtaining highly resolved spatial information of several compounds simultaneously across hair surfaces.

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The matrix effect in secondary ion mass spectrometry

Cited by 30 publications

References 32 publications

Metabolomics for a Millenniums-Old Crop: Tea Plant (Camellia sinensis)

Metabolomics for a Millenniums-Old Crop: Tea Plant (Camellia sinensis)

Simultaneous measurement of coefficient of thermal expansion and biaxial modulus of enamel thick films deposited on glass substrates by curvature technique

Mapping the Chemistry of Hair Strands by Mass Spectrometry Imaging—A Review

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