The MATRICS Consensus Cognitive Battery (MCCB): Performance and functional correlates

Lystad, June Ullevoldsæter; Falkum, Erik; Mohn, Christine; Haaland, Vegard Øksendal; Bull, Helen; Evensen, Stig; Rund, Bjørn Rishovd; Ueland, Torill

doi:10.1016/j.psychres.2014.08.060

Cited by 23 publications

(19 citation statements)

References 56 publications

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“…More recently, a meta-analysis study revealed that a variety of neurocognitive domains such as reasoning and problem solving, processing speed, attention and vigilance, working memory, verbal learning and memory, visual learning and memory, verbal fluency, and overall neurocognition are significantly associated with functional outcome 39. Lystad et al reported that among the MCCB cognitive domains, working memory was the most highly correlated with months of previous employment and social function evaluated by the SFS and was a significant predictor of social function 48. Torgalsbøen et al showed that MCCB attention/vigilance was a significant predictor of social and role functioning assessed by Global Functioning 52.…”

Section: Discussionmentioning

confidence: 99%

Relationship between social and cognitive functions in people with schizophrenia

Tominaga

Tomotake

Takeda

et al. 2018

NDT

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PurposeThe purpose of the present study was to examine clinical factors related to social function in people with schizophrenia.Patients and methodsThe participants were 55 stabilized outpatients with schizophrenia. Their mean age was 39.36 (SD =10.65) years. Social function was assessed using the Quality of Life Scale (QLS). Cognitive function was evaluated with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia, and the Drug-Induced Extrapyramidal Symptoms Scale.ResultsNeither the MCCB cognitive domain score nor composite score was correlated with the QLS scores. However, of the 10 MCCB subtests, the Trail Making Test Part A and the Brief Assessment of Cognition in Schizophrenia-Symbol Coding (BACS-SC) scores were positively correlated with the QLS scores. Among clinical variables, especially the PANSS negative syndrome scale score had a strong negative correlation with the QLS scores. Stepwise regression analyses showed that the PANSS negative syndrome scale score was an independent predictor of the QLS scores, and although the BACS-SC score predicted the QLS common objects and activities subscale score, the association was not so strong compared to the PANSS negative syndrome scale score.ConclusionThese results indicate that speed of processing evaluated by BACS-SC could predict some aspect of social function but negative symptoms have a much stronger impact on global social function in people with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Relationship between social and cognitive functions in people with schizophrenia

Tominaga

Tomotake

Takeda

et al. 2018

NDT

View full text Add to dashboard Cite

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“…The demographic and clinical characteristics of the participants are presented in Table . The recruitment process and test procedure of the participants in the schizophrenia group have been described elsewhere . Briefly, this sample consisted of 131 participants (92 men, 39 women) aged 18–65 years in a multisite vocational rehabilitation study (the Job Management Program [JUMP]) for adults with a main diagnosis of psychotic disorders, meeting the criteria according to the DSM‐IV .…”

Section: Methodsmentioning

confidence: 99%

Factor analyzing the Norwegian MATRICS Consensus Cognitive Battery

Mohn

Lystad

Ueland

et al. 2017

Psychiatry Clin Neurosci

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The theoretical domain structure of the MCCB could not be demonstrated in these Norwegian participants. Consonant with US studies, models with three and two factors had mediocre fit, and in the schizophrenia spectrum disorder group only. In both groups, the subtests Symbol Coding, Working Memory, and Learning were the most sensitive in tapping general neurocognitive performance, supporting US results. We conclude that in both Norway and the USA, the MCCB generates the same cognitive domains through factor analysis, but that these domains are not the ones suggested by the MATRICS project.

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“…The CPT-IP score was omitted when calculating the MCCB total score to avoid biasing predictive relationships. The MCCB neurocognitive composite score was calculated using the mean of the domain T -scores, as is consistent with prior publications 30 . The 5C-CPT was completed following the diagnostic and cognitive assessments.…”

Section: Methodsmentioning

confidence: 95%

Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia

et al. 2018

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Attentional dysfunction contributes to functional impairments in schizophrenia (SZ). Sustained attention is typically assessed via continuous performance tasks (CPTs), though many CPTs have limited cross-species translational validity and place demands on additional cognitive domains. A reverse-translated 5-Choice Continuous Performance Task (5C-CPT) for human testing—originally developed for use in rodents—was designed to minimize demands on perceptual, visual learning, processing speed, or working memory functions. To-date, no studies have validated the 5C-CPT against gold standard attentional measures nor evaluated how 5C-CPT scores relate to cognition in SZ. Here we examined the relationship between the 5C-CPT and the CPT-Identical Pairs (CPT-IP), an established and psychometrically robust measure of vigilance from the MATRICS Consensus Cognitive Battery (MCCB) in a sample of SZ patients (n = 35). Relationships to global and individual subdomains of cognition were also assessed. 5C-CPT and CPT-IP measures of performance (d-prime) were strongly correlated (r = 0.60). In a regression model, the 5C-CPT and CPT-IP collectively accounted for 54% of the total variance in MCCB total scores, and 27.6% of overall cognitive variance was shared between the 5C-CPT and CPT-IP. These results indicate that the reverse translated 5C-CPT and the gold standard CPT-IP index a common attentional construct that also significantly overlaps with variance in general cognitive performance. The use of simple, cross-species validated behavioral indices of attentional/cognitive functioning such as the 5C-CPT could accelerate the development of novel generalized pro-cognitive therapeutics for SZ and related neuropsychiatric disorders.

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The MATRICS Consensus Cognitive Battery (MCCB): Performance and functional correlates

Cited by 23 publications

References 56 publications

Relationship between social and cognitive functions in people with schizophrenia

Relationship between social and cognitive functions in people with schizophrenia

Factor analyzing the Norwegian MATRICS Consensus Cognitive Battery

Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia

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