The mathematical formula of the intravaginal ejaculation latency time (IELT) distribution of lifelong premature ejaculation differs from the IELT distribution formula of men in the general male population

Janssen, Paddy K.C.; Waldinger, Marcel D.

doi:10.4111/icu.2016.57.2.119

Cited by 16 publications

(26 citation statements)

References 16 publications

(41 reference statements)

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“…Moreover, the mathematical formula of the Gumbel Max IELT distribution of men with lifelong PE is useful for epidemiological research of the IELT among men with lifelong PE, when the number of men with lifelong PE is known. The study of Janssen et al ( 23 ) provided also indications that the prevalence of lifelong PE in Western countries may be as low as about 1%.…”

Section: Introductionmentioning

confidence: 97%

“…The similar method and design of two prospective stopwatch studies of the IELT in the general population of five countries ( 8 , 9 ) and in a cohort of men with lifelong PE ( 6 ) enabled the formulation of a mathematical formula to calculate the prevalence of any IELT values in any Western Caucasian male population. This idea has recently been proposed and elaborated by Janssen et al ( 23 ). Janssen et al ( 23 ) introduced a new method in which the fitness of various well-known mathematical probability distributions are compared with the IELT distribution of two previous stopwatch studies of the Caucasian general male population ( 8 , 9 ) and a stopwatch study of Dutch Caucasian men with lifelong PE ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…This idea has recently been proposed and elaborated by Janssen et al ( 23 ). Janssen et al ( 23 ) introduced a new method in which the fitness of various well-known mathematical probability distributions are compared with the IELT distribution of two previous stopwatch studies of the Caucasian general male population ( 8 , 9 ) and a stopwatch study of Dutch Caucasian men with lifelong PE ( 6 ). It appeared that the IELT distribution of the three studies was a gamma distribution.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, by the Kolmogorov-Smirnov test the accuracy of fitness is expressed by the GOF. The study of Janssen et al ( 23 ) showed that there are more men with lifelong PE ejaculating within 30 and 60 seconds than can be extrapolated from the probability density curve of the Lognormal IELT distribution of men in the general population. In other words, it was shown that men with lifelong PE have a separate IELT distribution, e.g., a Gumbel Max IELT distribution, that can only be retrieved from the general male population Lognormal IELT distribution when thousands of men would participate in an IELT stopwatch study.…”

Section: Introductionmentioning

confidence: 99%

“…In other words, it was shown that men with lifelong PE have a separate IELT distribution, e.g., a Gumbel Max IELT distribution, that can only be retrieved from the general male population Lognormal IELT distribution when thousands of men would participate in an IELT stopwatch study. As this will always be difficult to perform, the mathematical formula of the Lognormal IELT distribution, as calculated by Janssen et al ( 23 ) appears to be useful for epidemiological research of the IELT at least when the number of men in a specific population is known. Moreover, the mathematical formula of the Gumbel Max IELT distribution of men with lifelong PE is useful for epidemiological research of the IELT among men with lifelong PE, when the number of men with lifelong PE is known.…”

Section: Introductionmentioning

confidence: 99%

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The pathophysiology of lifelong premature ejaculation

Waldinger

2016

Transl. Androl. Urol.

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For many decades it has been thought that lifelong premature ejaculation (PE) is only characterized by persistent early ejaculations. Despite enormous progress of in vivo animal research, and neurobiological, genetic and pharmacological research in men with lifelong PE, our current understanding of the mechanisms behind early ejaculations is far from complete. The new classification of PE into four PE subtypes has shown that the symptomatology of lifelong PE strongly differs from acquired PE, subjective PE and variable PE. The phenotype of lifelong PE and therefore also the pathophysiology of lifelong PE is much more complex. A substantial number of men with lifelong PE not only have PE, but also premature erection and premature penile detumescence as part of an acute hypertonic or hypererotic state when engaged in an erotic situation or when making love. As both erectio praecox, ejaculatio praecox, detumescentia praecox, and the hypererotic state are part of the phenotype lifelong PE, it is argued that lifelong PE is not only a disturbance of the timing of ejaculation but also a disturbance of the timing of erection, detumescence and arousal. Since 1998, the pathophysiology of lifelong PE was thought to be mainly mediated by the central serotonergic system in line with genetic polymorphisms of specific serotonergic genes. However, by accepting that lifelong PE is characterized by the reversible hypertonic state the hypothesis of mainly serotonergic dysfunction is no longer tenable. Instead, it has been postulated that the pathophysiology of lifelong PE is mediated by a very complex interplay of central and peripheral serotonergic, dopaminergic, oxytocinergic, endocrinological, genetic and probably also epigenetic factors. Progress in research of lifelong PE can only be accomplished when a stopwatch is used to measure the IELT and the cut-off point of 1 minute for the definition of lifelong PE is maintained. Current use of validated questionnaires, neglect of stopwatch research, clinically inexperienced investigators and inclusion of anonymous men in a study performed by the Internet endanger the continuation of objective research of lifelong PE.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The pathophysiology of lifelong premature ejaculation

Waldinger

2016

Transl. Androl. Urol.

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Exciting Research in the Field of Sexual Psychopharmacology: Treating Patients with Inside Information

Janssen

2021

Modern CNS Drug Discovery

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Evaluation of Premature Ejaculation

Waldinger

2017

The Textbook of Clinical Sexual Medicine

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Introduction. Premature ejaculation (PE) is a prevalent, yet often underdiagnosed, sexual disorder that affects men of all ages. Identification of PE is hampered by stigma and embarrassment associated with the condition, and limited awareness that it is treatable. Because diagnosis informs treatment decisions that have an impact on clinical outcomes, the ability to diagnose PE accurately is vital to the successful management of this condition. Aim. Provide an overview of how to evaluate and diagnose PE. Methods. Review of the literature. Main Outcome Measures. The taxonomy of PE based on onset, time, type, and comorbidities. Results. Diagnosis of PE encompasses seven key steps: (i) Obtaining the patient's general medical and sexual history; (ii) Classifying the symptom on the basis of onset (e.g., lifelong or acquired PE), timing (e.g., prior to or during intercourse), and type (e.g., absolute/generalized or relative/situational); (iii) Involving the partner to determine their view of the situation and the impact of PE on the couple as a whole; (iv) Identifying sexual comorbidities (e.g., erectile dysfunction) to define whether PE is simple (occurring in the absence of other sexual dysfunctions) or complicated (occurring in the presence of other sexual dysfunctions); (v) Performing physical examination to check the man's sexual organs and reflexes; (vi) Identifying underlying etiologies and risk factors (e.g., endocrine-, urological-, or psychorelational-/psychosexual-related) to determine the primary cause of PE and any associated comorbidities; (vii) Discussing treatment options to find the most suitable intervention, according to the needs of the man and his partner. Conclusion.A greater understanding of how to diagnose PE correctly, and a more widespread use of a structured diagnostic approach, could lead to better treatment outcomes in the future.

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The mathematical formula of the intravaginal ejaculation latency time (IELT) distribution of lifelong premature ejaculation differs from the IELT distribution formula of men in the general male population

Cited by 16 publications

References 16 publications

The pathophysiology of lifelong premature ejaculation

The pathophysiology of lifelong premature ejaculation

Exciting Research in the Field of Sexual Psychopharmacology: Treating Patients with Inside Information

Evaluation of Premature Ejaculation

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