The Maternal–Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study

Abstract

Objective: This study aimed to investigate the maternal–neonatal outcomes of twin pregnancies of mothers with preeclampsia and their association with assisted reproductive technology (ART). Methods: A retrospective study on the clinical and maternal–neonatal outcome data of 698 women with twin pregnancies who delivered in our hospital from December 2013 to September 2021 was conducted. Continuous variables were analyzed using a Student’s t-test or Wilcoxon rank-sum test. Categorical variables were analyzed using the Chi-square test. The risk factors of twin pregnancies with preeclampsia were analyzed by logistic regression. Results: The rate of twin pregnancy complicated by preeclampsia was 17.62% (123/698). Logistic regression analysis showed that ART increased the risk of preeclampsia in twin pregnancies (AOR: 1.868, 95% CI: 1.187–2.941). Mothers with preeclampsia carrying twins conceived with ART had a higher rate of delivery at gestational week <34 (29.9% vs. 12.5%) and asphyxia of the neonate at 5 min after delivery (13.4% vs. 1.8%) than those with preeclampsia conceived without ART (p < 0.05). Conclusions: ART increases the risk of preeclampsia in twin pregnancies and the rate of adverse maternal–neonatal outcomes for twin pregnancies with preeclampsia. The policy of single embryo transfer is a method to reduce the adverse pregnancy outcomes of ART.

Clinical Features and Outcomes of Twin Pregnancies with Antiphospholipid Antibodies Positivity: A Retrospective Study

“…18 Several studies have explored the clinical characteristics and prognosis of twin pregnancy along with its comorbidities such as preeclampsia and gestational diabetes mellitus. [19][20][21] But twin pregnancies with APS or aPL positivity are rarely reported and remain a significant challenge for treatment. Here, we retrospectively evaluated the clinical characteristics and pregnancy outcomes of twin pregnancies with aPL positivity, which could broaden our insights into this rare but complex condition and optimize its management.…”

Clinical characteristics and perinatal outcomes of twin pregnancies with severe preeclampsia conceived by assisted reproductive technology: A retrospective study

“…Meanwhile, sPE seriously increases a woman's risk of developing or even dying from cardiovascular disease in the future [8,9] . In recent years, the incidence of PE has increased by 25%, which is related not only to the use of ART but also to the rising rate of twin pregnancies [10][11][12] . However, the effect of ART on the perinatal outcomes of twin pregnancies with severe PE has rarely been reported.…”