The maternal control in the embryonic development of zebrafish

Miccoli, Andrea; Valle, Luisa Dalla; Carnevali, Oliana

doi:10.1016/j.ygcen.2016.03.028

Cited by 32 publications

(18 citation statements)

References 250 publications

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“…2A and C). Sex hormones levels in the eggs depend strictly on maternal transfer during oogenesis (Miccoli et al, 2016); therefore, disruption of T levels in adults would result in imbalanced homeostasis of hormones in the eggs, as manifested by a general decrease in the different exposure groups, but a sharp increase in the M100 group (Fig. 2E).…”

Section: Reproductive Endocrine Disruptionmentioning

confidence: 99%

Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead

Chen

Wang

Zhang

et al. 2017

Environmental Pollution

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Section: Reproductive Endocrine Disruptionmentioning

confidence: 99%

Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead

Chen

Wang

Zhang

et al. 2017

Environmental Pollution

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“…Apoptosis is associated with mitophagy 30,31 . Knockdown of Drfundc1 decreased expression of the apoptosis-related genes baxb , bcl2a , bcl2b , and caspase3a 32,33,45,47,48 , contrasting to results of 293 T cells due to ectopic expression of Drfundc1 . This means that Drfundc1 knockdown interferes with apoptosis in zebrafish embryos.…”

Section: Discussionmentioning

confidence: 73%

“…Authors of several studies have claimed that autophagy tends to be accompanied by a certain degree of apoptosis 30,31 . We therefore measured expressions of the following autophagy- and apoptosis-related genes: atg5 , atg7 , atg12 , autophagy and beclin 1 regulator 1a ( ambra1a ), ambra1b , nucleoporin 62 ( p62 ), beclin1 , bcl2a , bcl2b , baxa , baxb , caspase3a , caspase9, p53 , and forkhead transcription factor 3a ( fox3a ) 32,33 .…”

Section: Resultsmentioning

confidence: 99%

Fundc1 is necessary for proper body axis formation during embryogenesis in zebrafish

Shen

Nibona

et al. 2019

Sci Rep

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FUN14 domain-containing protein 1 (FUNDC1) is a mitochondrial outer membrane protein which is responsible for hypoxia-induced mitophagy in mammalian cells. Knockdown of fundc1 is known to cause severe defects in the body axis of a rare minnow. To understand the role of Fundc1 in embryogenesis, we used zebrafish in this study. We used bioimaging to locate zebrafish Fundc1 (DrFundc1) with MitoTracker, a marker of mitochondria, and/or CellLight Lysosomes-GFP, a label of lysosomes, in the transfected ovary cells of grass carp. The use of Western blotting detected DrFundc1 as a component of mitochondrial proteins with endogenous COX IV, LC3B, and FUNDC1 in transgenic human embryonic kidney 293 T cells. DrFundc1 induced LC3B activation. The ectopic expression of Drfundc1 caused cell death and apoptosis as well as impairing cell proliferation in the 293 T cell line, as detected by Trypan blue, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and incorporation of BrdU. DrFundc1 up-regulated expression of both autophagy- and apoptosis-related genes, including ATG5, ATG7, LC3B, BECLIN1, and BAX in transgenic 293 T cells. A knockdown of Drfundc1 using short hairpin RNA (shRNA) led to midline bifurcation with two notochords and two spinal cords in zebrafish embryos. Co-injection of Drfundc1 mRNA repaired defects resulting from shRNA. Knockdown of Drfundc1 resulted in up- or down-regulation of genes related to autophagy and apoptosis, as well as decreased expression of neural genes such as cyclinD1, pax2a, opl, and neuroD1. In summary, DrFundc1 is a mitochondrial protein which is involved in mitophagy and is critical for typical body axis development in zebrafish.

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“…In addition to being involved in degradation, autophagy plays an important part in inflammation and pathogen clearance, and is implicated in cellular architectural changes that occur during differentiation and development [51]. Since autophagy is a fundamental evolutionarily conserved mechanism, and zebrafish development is strongly connected with it [35,52], we associated the developmental retardation, more evident in our I9E10gaa morphants, to altered autophagy [53]. Indeed, we observed significant changes in beclin1 and lc3b transcript levels and in p62 and Lc3b protein levels in the I9E10gaa morphants.…”

Section: -Brpa Increased Lysosomal Content In Morphantsmentioning

confidence: 99%

Glycogen storage in a zebrafish Pompe disease model is reduced by 3-BrPA treatment

Bragato¹,

Carra²,

Blasevich³

et al. 2020

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

The maternal control in the embryonic development of zebrafish

Cited by 32 publications

References 250 publications

Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead

Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead

Fundc1 is necessary for proper body axis formation during embryogenesis in zebrafish

Glycogen storage in a zebrafish Pompe disease model is reduced by 3-BrPA treatment

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