The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia

Abstract

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Classification of Preeclamptic Placental Extracellular Vesicles Using Femtosecond Laser Fabricated Nanoplasmonic Sensors

“…For example, Omatsu et al demonstrated that injecting phosphatidylserinephosphatidylcholine artificial microvesicles induced a preeclampsia-like disease in mice, 69 while He et al characterized the maternal blood lipidome and demonstrated that phospholipids including phosphadidyl cholines, phosphatidylethanolamines, and ceramides are possible biomarkers for preeclampsia. 70 In addition, one previous study used conventional Raman spectroscopy to characterize maternal serum and found minor but distinct differences in several peaks. 71 Confirming the importance of differences in the lipid content of EVs from preeclampsia, Chen et al have recently published that placental EVs that have vesicle-surface exposed phospatidyl serine (identified by annexin V binding) are increased in preeclamptic pregnancies.…”

“…Given EVs’ important and established role in cellular signaling, energy storage, and building of cellular membranes, as well as their clinical association with the vascular wall pathologies, the clear differences in lipid and phospholipid-associated peaks should not be understated. For example, Omatsu et al demonstrated that injecting phosphatidylserine-phosphatidylcholine artificial microvesicles induced a preeclampsia-like disease in mice, while He et al characterized the maternal blood lipidome and demonstrated that phospholipids including phosphadidyl cholines, phosphatidylethanolamines, and ceramides are possible biomarkers for preeclampsia . In addition, one previous study used conventional Raman spectroscopy to characterize maternal serum and found minor but distinct differences in several peaks .…”

Dissecting the Roles of Lipids in Preeclampsia

“…He et al demonstrated that PCs and LPCs were overall reduced in preeclampsia, which were linked to phospholipid metabolism [ 13 ]. Phospholipid metabolism is associated with preterm birth, a major clinical feature of preeclampsia [ 32 ].…”

“…Researchers have attempted to add lipid-related indicators to reach a higher detection rate since the predictive performance of using either clinical risk factors [ 14 ] or serum biomarkers [ 15 ] alone needs to be improved. He et al investigated the potential of identifying the severity of preeclampsia patients based on lipid signatures [ 13 ]. They employed a random forest (RF) model on selected lipids, obtaining an AUC value of 0.88.…”

“…They have pleiotropic roles in biology, ranging from a component of cell membranes, to cell communication, membrane trafficking, energy storage, and heat insulation [ 11 ]. Lipidomics is a subcategory of metabolomics that uses analytical chemistry techniques such as mass spectrometry and chromatography for the identification and quantification of lipids contained in biological samples [ 12 , 13 , 14 , 15 ]. Our understanding of the main lipid species involved in preeclampsia has substantially advanced in the past decade owing to advances in lipidomics.…”