The materials science beamline at the Swiss Light Source: design and realization

Pàtterson, B. D.; Abela, R.; Auderset, H.; Chen, Q.; Fauth, François; Gozzo, F.; Ingold, G.; Kühne, Hans‐Carsten; Lange, M.; Maden, D.; Meister, D.; Pattison, Philip; Schmidt, Th.; Schmitt, B.; Schulze-Briese, Clemens; Shi, M.; Stampanoni, Marco; Willmott, P. R.

doi:10.1016/j.nima.2004.11.018

Cited by 90 publications

(71 citation statements)

References 19 publications

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“…Additional high resolution X-ray measurements at room temperature were performed at the powder diffraction station of the materials science beamline at the Swiss Light Source ͑SLS, Villigen, Switzerland͒ 42 at an incident wavelength of Ϸ 0.44 Å ͑28 keV͒ using transmission geometry. Data were recorded by a position-sensitive microstrip detector ͑MYTHEN II͒.…”

Section: Methodsmentioning

confidence: 99%

Influence of lanthanum doping on the morphotropic phase boundary of lead zirconate titanate

Hinterstein

Schoenau

Kling

et al. 2010

Journal of Applied Physics

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A phase diagram for morphotropic ͑Pb 0.985 La 0.01 ͒͑Zr 1−x Ti x ͒O 3 is proposed based on a combination of X-ray and neutron powder diffraction experiments and complemented by transmission electron microscopy. Dependent on composition three regions are characterized. The stability range of tetragonal microdomains for high Ti contents, the stability range of rhombohedral microdomains for low Ti contents, and an intermediate stability range of nanodomains. All three regions exhibit a corresponding low temperature configuration. Temperature dependent diffraction revealed that lanthanum doping reduces the sensitivity of the structure to changes in temperature and composition. A continuous transition from pseudorhombohedral to tetragonal symmetry with an intermediate two-phase region at the morphotropic phase boundary is observed. A similar transition of low temperature superstructure phases from pseudorhombohedral to pseudotetragonal with an intermediate monoclinic phase governed by a continuous change in the oxygen octahedral tilt system from a − a − a − over a − a − c − to a 0 a 0 c − is identified.

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Section: Methodsmentioning

confidence: 99%

Influence of lanthanum doping on the morphotropic phase boundary of lead zirconate titanate

Hinterstein

Schoenau

Kling

et al. 2010

Journal of Applied Physics

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“…aberration-free optics such as those available at the SLS-MS beamline [4][5][6]. Under these conditions the profile broadening due to the optics can be considered purely Gaussian [4]; optimal calibration of the diffractometer and the detector [1]; negligible absorption effects.…”

Section: Aberrations In Debye-scherrer Geometrymentioning

confidence: 99%

“…All these aberrations are here analytically modelled for the case of a virtually aberration-free optics and fully parallel beam, as the Materials Science (MS) beamline at the SLS [4][5][6] can provide. The resulting expressions can be seamlessly incorporated in any data analysis program so as to be fully taken into account.…”

Section: Introductionmentioning

confidence: 99%

Instrumental profile of MYTHEN detector in Debye-Scherrer geometry

Gozzo¹,

Cervellino

Leoni

et al. 2010

Zeitschrift für Kristallographie

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Instrumental line profile / Profile aberrations / Synchrotron radiation XRPD / Debye-Scherrer geometry / Position sensitive detector / MYTHEN / TOPAS / PM2K / WPPM Abstract. The main aberrations affecting data collected with 1D position sensitive detectors in Debye-Scherrer capillary geometry are examined, and analytical corrections proposed. The equations are implemented in two of the most advanced software based on the Rietveld and Whole Powder Pattern Modelling methods, respectively, for structure and microstructure analysis. Application to MYTHEN, a fast single photon counting detector developed at the Swiss Light Source, is discussed in detail.

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“…Most monomeric RGD peptide-based tracers tend to have fast blood clearance accompanied by relatively low tumor uptake and rapid tumor washout, presumably because of the suboptimal receptor-binding affinity/selectivity and inadequate contact with Multimerization of cyclic RGD peptides has been repeatedly demonstrated to increase integrin affinity and enhance antiadhesion ability against integrin a v b 3 and thus significantly improve tumor targeting over the monomeric RGD analogs (11,12,(21)(22)(23)(24)(25)(26). The polyvalency effect has been most beneficial in tumors with low to medium integrin expression (26).…”

Section: Molecular Imagingmentioning

confidence: 99%

Advances in Anatomic, Functional, and Molecular Imaging of Angiogenesis

Hsu¹,

Chen²

2008

J Nucl Med

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Angiogenesis is a fundamental process in various physiologic and pathologic processes. The ability to visualize and quantify angiogenesis will allow early diagnosis and monitoring for clinical determination of angiogenesis states before, during, and after adjuvant antiangiogenic and therapeutic angiogenesis treatments.Key Words: angiogenesis; volumetric computed tomography (VCT); dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); integrin; vascular endothelial growth factor receptor (VEGFR) In recent years, angiogenesis has become one of the most important and intensely studied areas of cancer research, with the future holding great promise. Angiogenesis is a fundamental process in various physiologic and pathologic processes. The ability to visualize and quantify angiogenesis will allow early diagnosis and monitoring for clinical determination of angiogenesis states before, during, and after adjuvant antiangiogenic and therapeutic angiogenesis treatments. Investigators have identified more than 20 angiogenic growth factors, their receptors, and the details of their signal transduction pathways. Achievements with the vascular endothelial growth factor (VEGF) antibody bevacizumab (Avastin; Genentech) in combination with standard cytotoxic chemotherapy in metastasized colorectal cancer, breast cancer, and non-small cell lung cancer (1) are among them. However, although new antiangiogenic therapies are continually being introduced into clinical trials, we believe that the future success of these therapies will require the codevelopment of high-throughput, cost-effective imaging techniques with highly specific biomarkers of angiogenesis to determine optimal doses and individual response to therapy on a structural, functional, and molecular level. In the future, we believe that angiogenesis imaging will serve as an early diagnostic and monitoring tool for the clinical determination of angiogenesis states before, during, and after adjuvant antiangiogenic cancer therapy.J STRUCTURAL IMAGING OF ANGIOGENESISSeveral research and clinical imaging modalities are available for visualizing the structure of microvasculature such as intravital microscopy, CT angiography, contrast-enhanced ultrasound, and high-resolution magnetic resonance angiography. Multidetector CT angiography allows for larger scan volumes in less time with improved spatial and temporal resolution, making it possible to image different vascular phases using the same contrast bolus to compare the vasculature of tumors with that of normal organs. In addition, CT angiography provides a quick, noninvasive, low-dose alternative to conventional digital subtraction angiography in a research setting, and CT angiography has the potential to provide invaluable information about surrounding nonvascular structures and both arterial and venous systems. However, the spatial resolution of MDCT is still not enough for microvasculature visualization (2). To improve the number of photons produced per unit-area per second of benchtop x-ray sources, radiation micr...

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The materials science beamline at the Swiss Light Source: design and realization

Cited by 90 publications

References 19 publications

Influence of lanthanum doping on the morphotropic phase boundary of lead zirconate titanate

Influence of lanthanum doping on the morphotropic phase boundary of lead zirconate titanate

Instrumental profile of MYTHEN detector in Debye-Scherrer geometry

Advances in Anatomic, Functional, and Molecular Imaging of Angiogenesis

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