The mast cell in wound healing

Noli, Chiara; Miolo, Alda

doi:10.1046/j.0959-4493.2001.00272.x

Cited by 210 publications

(167 citation statements)

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“…Mast cells are well known mediators of injury-or infection-associated inflammation; however, recently additional functions for these cells have been suggested. In this respect, reports that suggest a role of mast cells in ECM-related processes during wound healing and fibrosis (Noli and Miolo, 2001;Puxeddu et al, 2003;Maurer et al, 2003) are of particular interest. Specifically, a role of mast cells in the aggregation of collagen fibers (Iba et al, 2004) or collagen lattice contraction (Moyer et al, 2004) has been investigated.…”

Section: Spherulocyte Role During Echinoderm Regenerationmentioning

confidence: 99%

Spherulocytes in the echinoderm Holothuria glaberrima and their involvement in intestinal regeneration

García‐Arrarás¹,

Schenk²,

Rodrígues‐Ramírez³

et al. 2006

Developmental Dynamics

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The holothuroid echinoderm Holothuria glaberrima can regenerate its intestine after a process of evisceration. Spherule-containing cells, the spherulocytes, appear to be associated with intestinal regeneration. We have used histochemistry and immunocytochemistry to characterize these cells and their role in the regeneration process. Spherulocytes are 10 -20 m in diameter with an acrocentric nucleus and spherule-like structures within their cytoplasm. They are found in the connective tissue of the intestine and mesentery of noneviscerated and regenerating animals. During the second week of regeneration, the number of spherulocytes in the regenerating intestine increases and a dramatic change in their morphology occurs. Together with the morphological change, the immunohistochemical labeling of the cells also changes; the antibodies not only recognize the spherule structures but also label the cellular cytoplasm in a more homogeneous pattern. Moreover, immunohistochemical labeling also appears to be dispersed within the extracellular matrix, suggesting that the cells are liberating their vesicular contents. Spherulocytes are found in other tissues of H. glaberrima, always associated with the connective tissue component. Our data strongly suggest that spherulocytes are involved in intestinal regeneration but their specific role remains undetermined. In summary, our data expand our knowledge of the cellular events associated with regeneration processes in echinoderms and provide for comparisons with similar processes in vertebrates.

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Section: Spherulocyte Role During Echinoderm Regenerationmentioning

confidence: 99%

Spherulocytes in the echinoderm Holothuria glaberrima and their involvement in intestinal regeneration

García‐Arrarás¹,

Schenk²,

Rodrígues‐Ramírez³

et al. 2006

Developmental Dynamics

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“…In this study, mast cells were found in close contact with fibroblasts. Mast cell activation is a characteristic feature of chronic inflammation, a condition that may lead to fibrosis as a result of increased collagen synthesis by a fibroblast [140][141][142][143][144].…”

Section: Cell-cell Interaction In Dermal Resident Cellsmentioning

confidence: 99%

Cell-Cell Interactions and Cross Talk Described in Normal and Disease Conditions: Morphological Approach

Ayuob¹,

Ali²

2012

Cell Interaction

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Additional information is available at the end of the chapter http://dx.doi.org/10.5772/48435 IntroductionThe contact between cells and their microenvironment is fundamental both during development and for the preservation of tissue structure. Picking out the signals coming from the surrounding environment enable cells to react promptly to changes that may occur. Various molecular mechanisms explain the ability of cells to sense the microenvironment could be grouped into two major classes: (1) the transmission of signals in the form of soluble molecules which interact with cellular receptors, such as growth factors, cytokines, hormones, etc., and (2) the interaction of cells with structural components of their environment, namely other cells and the extracellular matrix (ECM) [1].Cell-cell interactions are central to the function of many organ systems. A common theme for heterotypic cell interactions is the interaction of parenchymal cells with nonparenchymal neighbors with resultant modulation of cell growth, migration, and/or differentiation. Specifically, these interactions are of fundamental importance in physiology [2,3], pathophysiology [4,5], cancer [6,7] developmental biology [8,9], wound healing [10,11], and attempts to replace tissue function through 'tissueengineering' [12,13]. Further understanding of how cell-cell interactions modulate tissue function will allow us to gain fundamental biological insight as well as suggest approaches that will allow the manipulation of tissue function in vitro for therapeutic applications in vitro for therapeutic applications [14]. Cell-cell interaction and cross talk phenomena during embryonic periodCells are the true miracle of evolution. Once the basic building block, the eukaryotic cell, became available, the form of metazoans evolved by changing the arrangement of cells with respect to each other. Cell-cell interaction in embryo was described in literature to have a

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“…These substances are involved in various inflammatory and immunological reactions (11). Distribution of mast cells in different lesions involving lymph nodes (12), breast (6), uterus (13), cervix (14), and prostate (15) were studied, as well as its presence in wound healing (16), pterygium (17), atherosclerosis (18) and other disorders (2,6,7,9). The presence of mast cells in normal testis of man and other species has been reported by various authors (1).…”

Section: Introductionmentioning

confidence: 99%